【作者】 冒韵东；

【Author】 MAO Yun-dong Department of Clinical Reproductive Medicine,the First Affiliated Hospital of Nanjing Medical University/Jiangsu Province Hospital,Nanjing 210029

【机构】 南京医科大学第一附属医院； 江苏省人民医院生殖医学科；

【摘要】 卵巢低反应是助孕技术中的一个难点问题。目前没有统一的,被大家所接受的名称。应用较多的是"poor responders",即低反应。常规促排方案人绒毛膜促性腺激素(hCG)日<2～5个优势卵泡或成熟卵泡和(或)获取<3～6个卵母细胞可以诊断卵巢低反应。温和刺激或微刺激(mild/minimal stimulation)方案是为了避免在促排卵时发生卵巢过度刺激而设计的一类促排卵方案,后有人试行将这类方案用于卵巢低反应的治疗,如氯米芬或芳香化酶抑制剂联合人绝经期促性腺激素/卵泡刺激素(HMG/FSH),部分加用促性腺激素释放激素拮抗剂(GnRH-ant),多数获得了较好的结果。但目前没有报道用温和刺激或微刺激的方法诊断卵巢低反应。自然周期体外受精/卵胞浆内单精子注射(IVF/ICSI)的无刺激使得任何患者均成为"低反应",由于其避免了促排卵的许多缺点,可能在将来成为卵巢低反应患者重要的治疗手段。更多还原

【Abstract】 The treatment for poor ovary responders is a formidable task in assisted reproductive technologies.There is no uniform definition or uniform term of the poor ovary responder yet.In general, the"poor responders"refer to those with fewer than 2-5 dominant or mature follicles and/or less than 3- 6 oocytes retrived in a regular stimulating cycle.Mild or minimal stimulation is designed to avoid ovary hyperstimulation syndrome,with limited oocytes retrieved,which tactically results in"poor responder"and applied for those poor responders by some doctors.There are several different mild stimulation protocols, including clomiphene citrate/aromatases inhibitors plus HMG/FSH or GnRH-antagonist,and most of them have achieved some good results.In non-stimulated natural cycles,every patient will be a"poor responder"and many disadvantages of ovary stimulation protocols are avoided.With the treatment of natural cycles,some clinicians have achieved promising results in the poor responders.更多还原