【作者】 王芳； 罗红霞； 朱建成； 姜鹭； 郭兴华； 任发政；

【Author】 WANG Fang~1,LUO Hong-xia~1,ZHU Jian-cheng~1,JIANG Lu~2,GUO Xing-hua~3,REN Fa-zheng~(2,*) (1.Food & Bioengineering Department,Beijing Vocational College of Agriculture,Beijing 102442,China; 2.College of Food Science & Nutritional Engineering,China Agricultural University,Beijing 102442,China; 3.Institute of Microbiology,Chinese Academy of Sciences,Beijing 100083,China)

【机构】 北京农业职业学院食品与生物工程系； 中国农业大学食品科学与营养工程学院； 中国科学院微生物所；

【摘要】 益生菌在许多方面发挥了健康作用,然而与益生菌整肠功能、免疫调节功能等研究比较深入的益生功能相比较,其抗癌机制不太明确,抗癌功能颇受争议。本文综述动物实验和流行病学调查结果,支持益生菌具有抗癌功能的观点。目前对益生菌抗癌机制了解不多,其作用可能不是由单因素的机制来实现的,而是由包括直接作用和间接作用几种因素在内综合作用的结果。直接作用包括菌体本身或其活性代谢产物对致突变物的结合或降解作用,间接作用就是通过调节肠道菌群及其代谢酶活性、调节机体免疫功能、调节宿主相关的酶活力来起到抗癌作用。更多还原

【Abstract】 While a myriad of healthful effects have been attributed to the probiotics,perhaps the most controversial remains that of anticancer activity.The anti-cancer activity was indirectly evidenced by the in vivo studies in animals and epidemiological studies.However,the mechanisms involved have thus far been difficult to elucidate.The anti-carcinogenic effect may not be attributable to a single mechanism but rather to a combination of direct activity and indirect activities.Direct activity including the anti - genotoxic activity or anti - mutation against carcinogen by probiotics strains or the active metabolite;the indirect activity including modulation of the intestinal microflora and its metabolism,enhancing the host’s immune response,effects on physiology of the host.更多还原