【作者】 王玉玲； 宋玉波； 康维强； 宋达琳；

【Author】 Wang yu-ling Song Yu-bo Kang Wei-qiang Song Da-lin~* Department of Geriatric Medicine,Qingdao Geriatric Institute,Qingdao Municipal Hospital,266071,Qingdao

【机构】 南京医科大学附属青岛市市立医院护理部； 老年内科、青岛市老年医学研究所；

【摘要】 目的观察低血糖生成指数(LGI)膳食对老年糖尿病2型患者的获益性评估。方法将108例研究对象应用单纯随机单盲法分为LGI膳食组(54例)、对照组即非GIL膳食(54例);以60岁为年龄分界,LGI组中老年亚组(26例,70.7±4.3岁)和中年亚组(28例,54.7±4.3岁);对照组老年亚组(25例,70.7±4.3岁)和中年亚组(29例,70.7±4.3岁)。观察期为3个月后分别比较两组患者的膳食结构,观察指标包括血糖、血脂、BMI、HbAlC、以及胰岛素敏感指数(ISI)等。结果 LGI膳食组结构具有明显变化:LGI组膳食组患者血脂、BMI、HbAlC和ISI较对照组明显降低。老年患者LGI膳食干预后TG、TC和HDL-C可见改变(t=7.51、6.78和7.06,均为P<0.05),而LDL-C水平无明显变化(t=1.64,P>0.05);干预后两亚组比较,老年人LDL-C水平明显高于中年组(t=8.52,P<0.05):HbAlC和ISI指标表现为老年患者LGI膳食干预后明显改善(t=6.59,P<0.05)。LGI膳食干预后老年组低血糖发生率明显高于中年组(X2=7.05,P<0.01),心衰发生率也在老年组偏高且有统计学意义(X2=4.36,P<0.05)。而脑卒中、心绞痛发作和血压波动发生率未见差异。结论老年糖尿病患者LGI膳食利于血脂(特别是甘油三酯)、体重、HbAlC和胰岛素敏感性的控制,但潜在低血糖和心功能变化的风险。更多还原

【Abstract】 Objective:To evaluate the benefit of low glycaemic Index(LGI) diet for older with type 2 diabetes.Methods 108 consecutively enrolled type 2 Diabetes patients were separated to LGI group(54 cases) and non-LGI control group(54 cases).Subgroups were studied by old-age group(>60yer) and middle-age group(< 60yer).The parameters included of blood lipids,BML HbAlC,insulin sensitivity index(ISI)Interval 3 months.Results The consists of diet were changed,and the levels of blood lipids、BMI、HbA1C and ISI were controlled at LGI group.LGI old-age group demonstrated the levels of TG、TC and HDL-C were changed(t=7.51、6.78 and 7.06,P<0.05),but LDL-C was not statistical controlled compared to non-LGI old-age group(t=1.64,P>0.05);After LGI diet,level of LDL-C of older was more higher than middle-age group(t=8.52,P<0.05);At LGI old-age group HbAlC and ISI were controlled(t=6.59,P<0.05).At LGI old-age group, hypoglycemia(X2= 7.05,P<0.01) and heart failure(X2= 4.36,P<0.05).Stroke、angina and blood pressure did not show statistical difference between old-age and middle-age group.Conclusions LGI diet benefit to TG,MBI,HbAlC and insulin sensitivity for older with type 2 diabetes,but maybe high risk at hypoglycemia and heart failure.更多还原