【作者】 李海聪； 王博元； 杨学青； 李求兵； 戴琪； 王燕； 陈晓光； 马明； 田心； 赵东；

【Author】 Haicong LI Xueqing YANG Qiubing LI et al. (Geriatric Department,China-Japan Friendship Hospital)

【机构】 卫生部中日友好医院老年病科；

【摘要】 【目的】研究中医药治疗老年顽固性失眠的临床疗效。【方法】老年顽固性失眠患者406例随机分为中医治疗组(210例)和对照组(196例),分别采用中医辨证论与西药艾司唑仑治疗,并观察治疗前后PSQI、HAMD、HAMA、TESS等的变化,以比较和判断两者的临床疗效。【结果】中医药能显著降低失眠患者的PSQI各项因子的评分和总分评分,特别是显著缩短患者的睡眠潜伏期,提高其睡眠效率,延长其总睡眠时间,改善患者的临床症状,达到患者的生理睡眠要求。其有效率达到82.9%,总体疗效高于艾司唑仑(67.3%)。其不良反应如:嗜睡、口干、头晕、便秘及反跳性失眠均明显少于艾司唑仑。【结论】中医药治疗老年顽固性失眠有良好的临床疗效,且疗效优于艾司唑仑。更多还原

【Abstract】 [Objective]To study the efficacy and safety of traditional Chinese medicine(TCM) on chronic insomnia in elderly patients. [Methods]406 cases of chronic insomnia in elderly patients were assigned to two groups,the test group included 210 cases treated with TCM according to syndrome differentiation and control group included 196 cases treated with Estazolam.And then the scores of Pittsburgh sleep quality index (PSQI),Hamilton depress scale(HAMD),and Hamilton anxiety rating scale(HAMA) were recorded and compared with before and after the treatment. [Results]The scores of PSQI,HAMD,and HAMA after treattment were significantly reduced comparison with those before treatment(P<0.001).The efficacy rates(82.9%) of test group was higher than that(67.3%) of control group(P<0.001).The common adverse reactions,such as drowsiness, dizziness,dry mouth,constipation,in test group were less than in control group(P<0.05). [Conclusion]Traditional Chinese medicine has better efficacy and less side effects than Estazolam on insomnia in elderly patients.更多还原