β-arrestin2 plays a critical role in reward behaviors induced by cocaine

【作者】 刘星； 尹旭明； 黄冰； 马兰；

【机构】 复旦大学上海医学院药理研究中心；

【摘要】 Besides its role in desensitization and internalization of receptors,β-arrestin2 facilitates G protein-independent signaling through its ability to scaffold various signaling molecules.β-arrestin2 is widely distributed in the central nervous system,and mediates signal transduction of brain circuit.The aim of the present study was to investigate the role ofβ-arrestin2 in reward behaviors induced by cocaine.We assessed the conditioned place preference(CPP)induced by low(10 mg/kg),moderate(20 mg/kg)and high(30 mg/kg)doses of cocaine in Arrb2-/-mice and Arrb2+/+controls.In the Arrb2-/-mice,moderate and high,but not low,dose of cocaine induced pronounced increases of CPP scores,which were higher than those in the Arrb2+/+mice.Moreover,cocaine-induced locomotor activity was significantly lower in Arrb2-/-mice than that of Arrb2+/+littermate controls.Taken together,our results suggest a potential role ofβ-arrestin2 in the cocaine-induced rewarding behaviors.更多还原

【Abstract】 Besides its role in desensitization and internalization of receptors,β-arrestin2 facilitates G protein-independent signaling through its ability to scaffold various signaling molecules.β-arrestin2 is widely distributed in the central nervous system,and mediates signal transduction of brain circuit.The aim of the present study was to investigate the role of β-arrestin2 in reward behaviors induced by cocaine.We assessed the conditioned place preference(CPP) induced by low(10 mg/kg),moderate(20 mg/kg) and high(30 mg/kg) doses of cocaine in Arrb2-/-mice and Arrb2+/+ controls.In the Arrb2-/-mice,moderate and high,but not low,dose of cocaine induced pronounced increases of CPP scores,which were higher than those in the Arrb2+/+ mice.Moreover,cocaine-induced locomotor activity was significantly lower in Arrb2-/-mice than that of Arrb2+/+ littermate controls.Taken together,our results suggest a potential role of β-arrestin2 in the cocaine-induced rewarding behaviors.更多还原