【作者】 刘灿丽； 王家平； 袁曙光； 闫东； 郭立； 郝金刚；

【Author】 Wangjia-ping,liu can-li,Yuan Shu-guang,Yan Dong.Guo li,Hao jin-gang。(The Second Affiliate Hospital of Kunming Medical College,kunming,650101,china)

【机构】 云南昆明医学院第二附属医院放射科磁共振室；

【摘要】 目的观察原发性肝癌TACE术前后PWI的特点以及分析灌注参数的变化,探讨PWI在评价原发性肝癌TACE疗效中的临床应用价值。方法收集资料较齐全的32例首次行TACE的原发性肝癌患者,于术前2～3天及术后1～2月行MRI平扫、增强及灌注成像。然后绘制TSC,根据TSC的信息采用最大斜率法计算灌注参数。结果肝癌TACE术后病灶中心、病灶边缘HAP、TLP、HPI与术前相比具有统计学意义(P<0.05);7例TSC形态基本为平直的曲线,22例TSC形态波动幅度较TACE前减少,3例TSC形态无明显变化。结论PWI是一种功能检查方法,可反映组织微循环血流动力学情况,提供肿瘤血管生成的灌注定量信息,可作为TACE术随访检查手段。更多还原

【Abstract】 Objective To expore the clinical value of PWI to the TACE of primary hepatic carcinoma, by observing the charater of PWI and analysising the change of perfusion parameters.Methods 32 cases of primary hepatic carcinoma were collected,MRI routine Plain scan、enhancement and PWI were performed for the first TACE before2～3days and after1-2month of TACE.Then drawing TSC, perfusion parameters was calculated by slope analysis method depending on the TSC.Result Compared to before TACE,after TACE the HAP、PHI、TLP of center、edge having significant statistics(p<0.05);22 cases the TSC fluctuation range decreased;7cases of TSC was straight curve;3 cases of TSC was no changed before and after TACE.Conclusion PWI is a functional examination method, can accurately reflect the hemodynamic change of lesions.providing perfusion information of tumor angiogenesis,can be used follow-up after TACE.更多还原