【作者】 杨辉； 罗友华； 李成付； 黄恺飞； 黄亦琦；

【Author】 YANG Hui,LUO Youhua,LI Cheng fu, HUANG Kaifei,HUANG Yiqi (Xiamen Medical Institute,Xiamen 361003,China)

【机构】 厦门市医药研究所；

【摘要】 目的:优选复方咽舒宁水提液的陶瓷膜微滤精制工艺.方法:以复方中有效成分表告依春和哈巴俄苷转移率、除杂率为指标,采用单因素试验法优选陶瓷膜孔径,并以体外抑菌活性验证陶瓷膜微滤的精制效果.结果:最优陶瓷膜孔径为200 nm,进口压力为0.2 MPa,当储液桶中药液量无法循环时,加相当于膜滤系统最少循环量的水顶洗1次,当膜滤液量等于原液量时结束微滤.该陶瓷膜微滤液的表告依春和哈巴俄苷转移率分别为93.77%和82.67%、除杂率为24.64%.复方咽舒宁水提液的陶瓷膜微滤液和原液对5种咽炎致病菌的MIC和MBC无明显差异.结论:200 nm陶瓷膜微滤技术合理可行,可作为复方咽舒宁水提液的精制工艺.更多还原

【Abstract】 Objective:To optimize the ceramic membrane microfiltration purifying technology of the decoction of Yanshuning Compound.Method:Single factor test method was used to optimize the ceramic membrane aperture,according to indexes of the transfer rates of Epigoitrin and Harpagoside and removal ratio of impurity.And the ceramic membrane microfiltration refining effect was verified according to the vitro antibacterial activity.Results;The optimal ceramic membrane aperture was 200 nm.The import pressure was 0.2 MPa.When the liquid volume in the reservoir barrel was not enough to circulate,water with equal to the amount of the least circulation volume of the membrane filtration system was added to the barrel once.When the filtration volume is equivalent to the original,it was ended.The transfer rates of Epigoitrin, Harpagoside and the removal ratio of impurity were respectively(%):93.77,82.67 and 24.64. There were no significant differences between MIC and MBC of the five kinds of pharyngitis bacteria of the ceramic membrane microfiltration refining fluid and the original fluid.Conclusion:The 200 nm ceramic membrane microfiltration technology is reasonable and feasible.It can be used as the purifying technology of the decoction of Yanshuning Compound.更多还原