【作者】 李岚； 樊民； 倪灿荣； 梁春； 任雨笙； 吴宗贵；

【Author】 LI Lan1,FAN Min2,NI Can-rong3,LIANG Chun2,REN Yu-sheng2,WU Zong-gui2(1.Fourth Medical Department,PLA 411 Hospital,Shanghai 200081,China;2.Department of Cardiovasology,Changzheng Hospital,3.Department of Pathology,Changhai Hospital,Second Military Medical University,Shanghai 200003,China)

【机构】 解放军第411医院内四科； 第二军医大学长征医院心内科； 第二军医大学长海医院病理科；

【摘要】 目的:探讨诱导型环氧合酶(COX-2)在兔主动脉粥样硬化(atherosclerosis,AS)组织中的表达及其与斑块易损性之间的关系。方法:以高脂饲料喂养建立兔主AS模型,并与正常饲料组对照。喂养12周后,取兔主动脉标本,行HE及免疫组化染色,观察COX-2、基质金属蛋白酶-2(MMP-2)、Ⅰ型和Ⅲ型胶原在AS斑块组织中的表达。结果:COX-2仅见于AS斑块,正常动脉壁无表达。AS组COX-2免疫组化染色强度均显著高于正常对照组(P<0.05)。AS组Ⅰ、Ⅲ型胶原和MMP-2免疫组化染色强度均显著高于正常对照组(P<0.05),Ⅰ/Ⅲ型胶原的比例增加。结论:COX-2在兔主动脉AS斑块中的高表达可能增加斑块的易损性。更多还原

【Abstract】 AIM: To evaluate the expression of COX-2 in rabbit atherosclerotic plaque and the relationship between COX-2 and plaque vulnerability.METHODS: The rabbit aortic atherosclerotic model was developed by high cholesterol feeding.Rabbit aorta specimens were measured by HE staining and immunohistochemical staining of COX-2,MMP-2 and I/III collagen.RESULTS: COX-2 was found in atherosclerotic plaques but not in healthy or nonatherosclerotic vascular walls.COX-2,MMP-2 and I/III collagen was induced in atherosclerotic plaque lesions,implicating a relationship between COX-2 and plaque vulnerability.CONCLUSION: Overexpression of COX-2 enhances rabbit atherosclerotic plaque vulnerability.更多还原