【作者】 吕安林； 李丹； 贾国良； 陈丹； 苑媛；

【Author】 L An-lin,LI Dan,JIA Guo-liang,CHEN Dan,YUAN Yuan(Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi′an,Shaanxi 710032,China)

【机构】 第四军医大学西京医院心血管内科；

【摘要】 目的:观察巴曲酶防治经皮冠状动脉介入治疗(PC I)术后再狭窄的临床疗效。方法:100例PC I术后患者随机分成两组:A组为常规低分子肝素抗凝治疗;B组在常规低分子肝素抗凝基础上,于术后第1、3、5天静滴巴曲酶15、10、10 BU。术后7 d观察纤维蛋白原(FIB)、PT、PLT、RBC的变化,术后6月观察两组的临床症状、心功能及超声心动图和实验室指标。结果:A组临床症状显效率60%,总有效率92%;B组临床症状显效率90%,总有效率98%。B组FIB显著降低,其它检查无明显变化,凝血酶原时间、活化的部分凝血酶原时间、血小板及红细胞等均无显著变化(P>0.05)。A组左室射血分数(LVEF)由(50±6)%上升为(56±4)%,B组LVEF由(51±7)%上升为(61±5)%(P<0.01),B组PC I术后6月LVEF改善明显。在终点事件中,A组死亡2例,非致死性心肌梗死3例,难治性心绞痛5例;B组无上述事件发生。结论:巴曲酶对PC I术后再狭窄的防治具有显著的疗效,心功能的恢复显著,治疗中无出血等不良反应。更多还原

【Abstract】 AIM: To investigate the preventive and curing effect of Batroxobin on restenosis following percutaneous coronary intervention(PCI).METHODS:The total of 100 patients post PCI were divided into group A and group B.Group A were treated regularly with low molecular weight heparin(LMWH).On the basis of LMWH therapy,group B were given batroxobin at 1 d(15 BU),3 d(10 BU) and 5 d(10 BU).The changes of FIB,PT,PLT,RBC were observed in the former three days.The clinical characteristics,heart function and changes of echocardioghraphy and laboratory indexes were observed.(RESULTS): The effective percentage of the clinical sign in group A was 60%,while the total effective percentage was 92%.The effective percentage of the clinical sign in group B was 90%,while the total effective percentage was 98%.At the same time,FIB in group B after treatment decreased dramatically.PT,APTT,PLT and RBC did not change significantly(P>0.05).LVEF in group A were increased from(50±6)% up to(56±4)%,LVEF in group B from(51±7)% up to(61±5)%(P<0.01).LVEF in group B recovered dramatically in 6 months after PCI.In the terminal events,there were two dead patients,three nonfatal infarction patients and five angina patients in group A;There were no(events) in group B.CONCLUSION: Batroxobin remarkably prevents the development of post PCI restenosis.Heart functions are recovered dramatically.Moreover,there are no complications such as hemorrhages etc.更多还原