Nuclear Factor(Erythroid-Derived 2)-Like 2Activation-Induced Hepatic Very-Low-Density Lipoprotein Receptor Overexpression in Response to Oxidative Stress Contributes to Alcoholic Liver Disease in Mice

【作者】 王志刚； Xiaobing Dou； Songtao Li； Zhenyuan Song；

【Author】 Zhigang Wang;Xiaobing Dou;Songtao Li;Zhenyuan Song;Department of Kinesiology and Nutrition,University of Illinois at Chicago;College of Laboratory Medical Science,Harbin Medical University at Daqing;College of Life Science,Zhejiang Chinese Medical University;

【机构】 哈尔滨医科大学大庆校区； Department of Kinesiology and Nutrition,University of Illinois at Chicago； College of Life Science,Zhejiang Chinese Medical University； College of Laboratory Medical Science,Harbin Medical University at Daqing；

【摘要】 <正>Purpose:Chronic alcohol consumption leads to hypertriglyceridemia,which is positively associated with alcoholic liver disease(ALD).However,whether and how it contributes to the development of fatty liver and liver injury are largely unknown.Methods:Male C57BL/6 mice weighing 25±0.5 g were randomly assigned to two groups and fed for 5 weeks with liquid diets containing(in percent of energy intake)18%protein,35%fat,12%carbohydrate,and 35%either更多还原