The Clathrin Adaptor Proteins ARH,Dab2 and Numb Play Distinct Roles in NPC1L1-versus LDL Receptor-mediated Cholesterol Uptake

【作者】 魏健； 付真彦； 李培山； 缪红华； 马依彤； 李伯良； 宋保亮；

【Author】 Jian Wei;Zhen-Yan Fu;Pei-Shan Li;Hong-Hua Miao;Yi-Tong Ma;Bo-Liang Li;Bao-Liang Song;Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences;Department of Cardiovascular Medicine,First Affiliated Hospital of Xinjiang Medical University;College of Life Sciences,Wuhan University;

【机构】 Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences； Department of Cardiovascular Medicine,First Affiliated Hospital of Xinjiang Medical University； College of Life Sciences,Wuhan University；

【摘要】 <正>The uptake of circulating low density lipoproteins(LDL)is mediated by LDL receptor(LDLR)through clathrin-dependent endocytosis.At the early stage of this process,adaptor proteins ARH and Dab2 specifically bind the endocytic signal motif in LDLR and recruit clathrin/AP2 to initiate the internalization.On the other hand,intestinal cholesterol is absorbed by Niemann-Pick Cl-Like 1(NPC1L1)through clathrin-dependent endocytosis.更多还原