Functional interaction of KLF5 with Sp1 upregulates apelin in vascular smooth muscle cells

【作者】 吕心瑞； 郑斌； 温进坤；

【机构】 河北医科大学；

【摘要】 <正>Objective:Apelin,identified as the endogenous ligand of the orphan G-protein-coupled receptor APJ,exerts a variety of cardiovascular effects,but the molecular mechanism of apelin expression regulation in vascular cells is poorly described.The Sp/ KLF family of pro-teins,such as krppel-like factor 5(KLF5) and Sp1 have been attested to regulate the ex-pression of many genes in cardiovascular cells.Am80,a synthetic retinoic acid receptorα-specific agonist,exhibits specific biological effects on vascular pathophysiology by regulat-ing differentiation- and proliferation-related genes.In the present study,we investigated the roles of KLF5更多还原