Guanine nucleotide exchange factor Vav1 plays a distinguished role in T-cell calcium signaling by binding to Calmodulin

【作者】 李石洋； 刘耀辉； 万雅娟； 杜明娟； 李鸿鹭； 张翠竹； 曹又佳；

【机构】 南开大学医学化学生物学国家重点实验室；

【摘要】 <正>Vav1,a guanine nucleotide exchange factor specifically expressed in hematopoietic cells,consists of multiple structural domains and plays multiple roles in T cell activation.The cal-ponin homology(CH) domain of Vav1 participates in regulating calcium flux,a key com-ponent of T cell receptor(TCR) mediated signaling pathways,and the activation of tran-scription factors including nuclear factor of activated T cells(NFAT).Our previous work indicated that the CH domain exhibited this function through interacting with calmodulin(CaM).Focusing on the role of Vav1 in T cell calcium regulation,we narrowed down a key region within CH更多还原