Herpes simplex virus infection of T cell and interfering with its function

【作者】 杨寅； 王雨； 陈祥东； 张翠竹； 曹又佳；

【机构】 南开大学；

【摘要】 <正>Herpes simplex virus(HSV),featured by its ability to infect and establish latency in human dorsal root ganglia,is one of the viruses hardly to cope with.T cell is critical in HSV im-munity,but can not prevent HSV reactivation,indicating HSV have ability to interfere with T cell function.Using Jurkat cells as a T cell model system,we demonstrated that HSV-1 can infect and replicate in T cell.The proof was in three folds:1)The representative mRNAs of immediate early,early and late genes of HSV-1 were detected in更多还原