癣清双酶(DNA-2E)抗真菌药效学的实验研究

【作者】 欧守珍； 莫燕娜； 陈世民； 高凌峰； 吉丽敏； 王丹妹； 何佟； 虞道瑞；

【Author】 Ou Shou-zhen Bei-ning Gao Ling-feng Zeng Xiang-zhou (Hainan Medical College,Haikou 571101,Hainan,China)

【机构】 海南医学院机能学实验室；

【摘要】 目的:研究癣清(DNA-2E)的抗真菌药效学作用。方法:采刚浓度梯度法研究癣清(DNA-2E)对红色毛癣菌、须状毛癣菌的最低抑菌浓度(MIC)。结果:癣清(DNA-2E)对红色毛癣菌、须状毛癣菌的最低抑菌浓度(MIC)范围分别为0.0625～0.125mg/ml和0.03125～0.125mg/ml,两组比较差异无显著性:2%和496癣清(DNA-2E)对豚鼠须状毛癣菌感染足癣,体癣有较好疗效,与1%足光粉比较差异无显著性,与蒸镏水组比较差异非常显著性;4%和6%癣清(DNA-2E)止瘁作用与1%足光粉相比差异无显著性,与蒸镏水组比较差异非常显著性。结论:癣清(DNA-2E)外用具有较好的抗真菌及止痒作用。更多还原

【Abstract】 Objective:To study the effects of DNA-2E in antimycotic phannacodynamics. Methods:The minimal inhibitory concentrations(MIC) were obtained by concentration gradient method for Trichophyton rubrum and beard-like Trichophyton. Results:The ranges of MIC were 0.0625～0.125mg/ml and 0.03125～0.125mg/ml respectively for Trichophyton rubrum and beard-like Trichophyton,which showed no significant difference between two groups.Both 2%and 4%of DNA-2E had better effects on ringworm of both feet and body resulted from infection of beard-like Trichophyton in guinea pig,which showed very significant difference compared to distilled water and no significant difference compared to 1%Zuguang powder.Both 4%and 6%of DNA-2E had better effects of relieving itching compared to distilled water and no significant difference compared to 1%Zuguang powder.Conclusion: DNA-2E has better effects on antimyeotic and relieving itching by external use.更多还原