进展期胃癌术后早期腹腔灌注化疗的临床评价及护理

【作者】 刘志燕； 邱英； 郭成香；

【机构】 河南省肿瘤医院普外三；

【摘要】 目的:探讨进展期胃癌(AGC)术后早期腹腔温热低渗灌注化疗(IHCP)的临床价值。方法:AGC术后患者32例随机分为观察组16例,术后早期行IHCP;对照组16例行静脉化疗。观察化疗毒副作用和并发症;患者1、2年腹腔内肿瘤复发和肝转移以及1、2年生存率。结果观察组年肿瘤复发率、肝转移率均低于对照组(P<0.05);观察组1年生存率(88.1%)与对照组(75.6%)差异无统计学意义(P>0.05),2年生存率(66.7%)高于对照组(43.9%)(P<0.05)。观察组化疗毒副作用比对照组轻,无严重并发症。结论:术后早期IHCP对AGC术后腹腔肿瘤复发与肝转移有良好防治作用。更多还原

【Abstract】 Objective To investigate the clinical value of early postoperative intraperitoneal hyperthermic chemoperfusion (IHCP) for patients with advanced gastric carcinoma(AGC).Methods 32 patients with postoperative AGC were randomly divided into observation group (n=16) and control group (n=16).Early postoperative IHCP was performed in the observation group,while intravenous chemotherapy was performed in the control group.Side effects and complications of chemotherapy were then monitored between the two groups.Peritoneal recurrence,liver metastasis and survival rate of 1 year or 2 years were recorded.Results The annual peritoneal recurrence rate and liver metastasis rate in the observation group were lower than those of the control group (P<0.05).There was no statistical significance about the one year survival rate in both the observation group (88.1%)and the control group (75.6%),while the two year survival rate in the observation group(66.7%) was higher than that of the control group(43.9%)(P<0.05).Comparing the side effects with the control group,the observation group had no severe complication.Conclusion The early postoperative IHCP has obvious effect on preventing the tumor recurrence in the peritoneal cavity and liver metastasis in patients with AGC.更多还原