【作者】 胡杰英； 蒋东霞； 范瑞华； 郭金东； 魏旭东； 符粤文； 宋永平；

【Author】 Hu Jieying~1,Jiang Dongxia~2,Fan Ruihua~2,Guo jindong~2,Wei Xudong~2, Fu Yuewen~2,Song Yongping~2 (1,Henan Institute of Tumor;2,Henan Tumor Hospital,Zhengzhou,China.)

【机构】 河南省肿瘤研究所； 河南省肿瘤医院；

【摘要】 目的探讨骨髓增生异常综合征(MDS)患者染色体异常核型在MDS亚型中的分布及核型分析在该疾病向白血病转化和预后中的意义。方法对69例MDS患者采用骨髓短期培养法制备染色体标本,并用R显带方法进行染色体核型分析。结果MDS患者中异常核型率为42.03%(29/69)。29例异常核型患者中伴有+8异常3例,20q-4例,5q-3例,-72例,7q-1例,复杂核型7例,17号异常2例,其它异常7例。随访的40例患者中,15例死亡,5例转化为急性白血病。结论核型分析在MDS患者向白血病转化及预后中有重要意义。某些特殊的核型可能具有独立的预后意义。更多还原

【Abstract】 Objective To investigate the distribution of chromosomal abnormal karyotype in myelodysplastic syndrome(MDS) subgroups,and study the significance of karyotype analysis in the transformation into leukemia and prognosis of MDS. Methods The chromosomes of the 69 patients with myelodysplastic syndrome were prepared with brief culture of bone marrow,and the karyotypes were analysed by R banding technique.Results Twenty nine out of 69 patients had chromosome abnormalities.Among the 29 abnormal chromosomes,+8 presented in 3 cases,20q- in 4 cases,5q- in 3 cases,-7 in 2 cases,7q- in 1 case,and complex karyotype in 7 cases, chromosome 17 abnormality in 2 cases,the remain 7 cases were other chromosome abnormalities.Among the 40 followed-up patients,15 patients died and 5 patients turn into acute leukemia.Conclusion Karyotype analysis is very important in the change into leukemia and forecast the prognosis of MDS.Some special karytypes may have independent prognostic significance.更多还原