【作者】 张爱华； 洪峰；

【Author】 Aihua Zhang,~1Hong Feng,~1Guanghong Yang,~1Xueli Pan,~1Xianyao Jiang,~1Xiaoxin Huang,~2 Xuexin Dong,~2Daping Yang,~2Yaxiong Xie,~1Luo Peng,~1 Li Jun,~1Changjun Hu,~1Li Jian,~1and Xilan Wang~1 1 Department of Toxicology,School of Public Health,Guiyang Medical University,Guizhou,People’s Republic of China;2 The 44th Hospital of People’ s Liberation Army,Guizhou,People’ s Republic of China

【机构】 Department of Toxicology School of Public Health,Guiyang Medical University；

【摘要】 <正>Inorganic arsenic(iAs) is a well-known human carcinogen recognized by the World Health Organization and the International Agency for Research on Cancer.In Guizhou province,arsenicosis caused by the burning of coal in unventilated indoor stoves is an unusual type of exposure.We examined the relationship between arsenic(As) exposure from the burning of coal in unventilated indoor stoves and genetic damage in humans,using cellular and molecular indices.The samples are selected villagers from Jiaole township,Guizhou province,China,in which the villagers had been exposed to milligram levels of As daily via food and air contaminated by the burning of As-containing coal in unventilated indoor stoves.The results showed that long-term As exposure may be associated with damage of chromosomes and DNA,gene mutations,gene deletions,and alterations of DNA synthesis and repair ability.更多还原

【Abstract】 Inorganic arsenic(iAs) is a well-known human carcinogen recognized by the World Health Organization and the International Agency for Research on Cancer.In Guizhou province,arsenicosis caused by the burning of coal in unventilated indoor stoves is an unusual type of exposure.We examined the relationship between arsenic(As) exposure from the burning of coal in unventilated indoor stoves and genetic damage in humans,using cellular and molecular indices.The samples are selected villagers from Jiaole township,Guizhou province,China,in which the villagers had been exposed to milligram levels of As daily via food and air contaminated by the burning of As-containing coal in unventilated indoor stoves.The results showed that long-term As exposure may be associated with damage of chromosomes and DNA,gene mutations,gene deletions,and alterations of DNA synthesis and repair ability.更多还原