【作者】 李波； 丁一； 罗春山； 田晓滨； 张一；

【Author】 Li Bo,Ding Yi,Luo Chun- Shan,et al.Department of Orthopaedics,the people’s hospital of gui zhou province,Guiyang 550002

【机构】 贵州省人民医院骨科；

【摘要】 目的:通过观察椎板切除术后硬膜外瘢痕粘连的形态学改变,探讨几丁糖-钛网联合运用对防治硬膜外瘢痕粘连形成的作用。方法:用80只成年家兔(体重2±0.2kg)制作椎板切除模型,在椎板缺损处分别覆盖等渗盐水(A组)、钛网(B组)、几丁糖(C组)以及几丁糖加钛网(D组),分别于2、4、8周电镜与光镜下观察瘢痕形态学的改变。结果:对照组瘢痕明显,钛网组可减轻硬膜周围的瘢痕包裹,有效的隔绝周围瘢痕组织与硬脊膜,几丁糖组有明确的抗瘢痕粘连,抑制炎症反应的作用,几丁糖加钛网组能有效的立体抑制硬膜周围瘢痕的增生。结论:几丁糖加钛网能有效的从立体上抑制椎板切除术后硬膜周围的瘢痕粘连。更多还原

【Abstract】 Objective To observe the morphology changes of epidural cicatricle accretion following laminectomy,and the effect of association apply of chitosan and titanium net in preventing its formation.METHODS:Eighty rabbits were operated with the laminectomy in this study and were divided into 4 groups:the defects of vertebral plate were covered with saline solution(group A),net of the titanium(group B),chitosan(group C)and intergrated chitosan and net of the titanium(group D).the morphology changes of scars were observed by electron microscope and light microscope at 2,4 and 8 weeks after operation.RESULTS:The scar formation was obvious.Net of the titanium can reduce the scar formation,and isolate it endorachis effectively.Chitosan can prevent the cicatricle accretion and stop the inflammatory reaction significantly.Howere intergrated chitosan and net of the titanium has a three -dimensional prevention of the scar hyperplasy.CONCLUSIONS:Chitosan and net of the titanium has a three-dimensional prevention of the scar hyperplasy after laminectomy.更多还原