【作者】 刘杰； 华赟鹏； 谭敏谊； 陈健文；

【机构】 中山大学附属第三医院； 中山大学附属第一医院； 中山大学药学院；

【摘要】 目的研究注射用参麦皂苷(SMI)的抗应激性以及对心肌缺血的保护作用。方法分别通过小鼠常压耐缺氧实验、急性脑缺氧实验和负重游泳实验,考察了SMI对小鼠应激性的影响;采用舌静脉注射垂体后叶素造成大鼠急性心肌缺血模型,观察SMI对模型大鼠心电图指标及心率的影响,考察SMI对大鼠心肌缺血的保护作用。结果与对照组比较,SMI5.2mg/kg、10.4mg/kg和20.8mg/kg剂量组均能延长常压耐缺氧实验小鼠的存活时间、快速断头后小鼠的张口喘气时间及小鼠负重游泳的时间;并且,与模型组比较,SMI7.2mg/kg和14.4mg/kg剂量组均可显著减轻垂体后叶素所引起大鼠的心电图J点位移、T波高度的改变。结论 SMI能提高小鼠的应激能力,并对垂体后叶素诱发的大鼠急性心肌缺血具有保护作用。更多还原

【Abstract】 Objective To investigate the effects of SMI on the anti-stress ability and protective effects on myocardial ischemia.Methods To investigate the effects of SMI on the stress ability in mice,the following experiments were conducted,acute anoxia by hypoxia under normal pressure and decapitation,swimming under burden,respectively;To investigate the protective effects of SMI on myocardial ischemia,the rats were given pituitrin through intravenous injection in rat tongue to induce acute myocardial ischemic,and electrocardiogram and heart rate monitored.Results The survival time,persistently gasping time and swimming time under burden of the SMI 5.2mg/kg、10.4mg/kg and 20.8mg/kg groups was prolonged comparing with the control group;The height changes of J point and T wave induced by pituitrin of the SMI 7.2mg/kg and 14.4mg/kg groups were significantly decreased comparing with the model group.Conclusion SMI can improve the stress ability in mice and has protective effect on acute myocardial ischemic in rats.更多还原