【作者】 陈呼和； 于芳汀； 杨展澜； 徐怡庄； 翁诗甫； 吴瑾光；

【Author】 CHEN Hu-he,YU Fang-ting,YANG Zhan-lan~*,XU Yi-zhuang,WENG Shi-fu,WU Jin-guang College of Chemistry and Molecular Engineering,State Key Laboratory of Rare Earth Material Chemistry and Application, Peking University,Beijing 100871,China

【机构】 北京大学化学与分子工程学院,稀土材料化学及应用国家重点实验室；

【摘要】 研究发现甘氨脱氧胆酸钠与Ca²⁺作用形成的钙盐溶解度比较低,甘氨脱氧胆酸钙（CaGDC₂）的溶度积为～1×10^-8,而正常人体胆汁中,往往存在相对较高浓度的甘氨脱氧胆酸钠以及相对较高浓度的Ca²⁺,却不产生相应的钙盐沉淀,这一"缓冲"作用的机理尚不清楚。我们采用浊度滴定、激光光散射光谱和红外光谱等方法研究了磷脂-甘氨脱氧胆酸钠（PC-GDC）体系对甘氨脱氧胆酸钙沉淀的"缓冲"作用,给出了可能的作用机理。更多还原

【Abstract】 Sodium glycodeoxycholate（GDC） and phospholipid（PC） mixed system was used to study the Ca²⁺-buffering capability of bile salt micelles.The calcium precipitation-buffering property of PC-GDC mixed micelles was studied by utilizing turbidity titration, quasi-elastic light scattering,and Fourier transform infrared spectroscopy.The results indicated that PC-GDC mixed micelles exhibited better calcium precipitation -buffering properties than GDC simple micelles.Globular mixed micelles showed much better calcium precipitation-buffering property than mixed disk micelles.Globular mixed micelles were aggregated to form secondary mixed micelles and ultimately nonstoichiometric precipitates of Na_nCa_m（GDC）_n+2mPC_x.更多还原