【作者】 戚玉敏； 何云； 刘双进； 李勇； 崔春翔； 刘慧； 王晶；

【Author】 QI Yu-min~1,HE Yun~2,LIU Shuang-jin~1,LI Yong~3,CUI Chun-xiang~1,LIU Hui~1,WANG Jing~1 (1.School of Materials Science & Engineering,Hebei University of Technoogy,Tianjin 300130 China; 2.Hospital of Hebei University of Technoogy,Tianjin 300130 China; 3.Equipment Department,Shenhua Hebei Guohua Cangdong Power Generation CO.LTD., Cangzhou 061113,China)

【机构】 河北工业大学材料科学与工程学院； 河北工业大学医院； 神华河北国华沧东发电有限责任公司；

【摘要】 通过XRD和表面接触角测量仪对化学法在Ti-15Mo-3Nb合金表面原位生成的生物薄膜进行物相组成与表面能测试,并根据GB/T16886.4-2003《医疗器械生物学评价第4部分:与血液相互作用试验选择》中规定的评价方法选择用动态凝血实验、溶血实验和血小板黏附实验对Ti-15Mo-3Nb和K₂Ti_nO_2n+1生物薄膜/钛合金生物材料的血液相容性进行对比研究,并从K₂Ti_nO_2n+1生物薄膜组成和表面能出发来探讨其与血液的作用机制。试验结果表明,K₂Ti_nO_2n+1生物薄膜具有更好的抗凝血作用,其溶血率大大<5%,表面黏附血小板的数量少且形态正常,该涂层优异的血液相容性与其组成和表面能直接相关,是一种具有应用价值的新型生物材料。更多还原

【Abstract】 The phase composition and surface energy of K₂Ti_nO_2n+1 bioogical film which was fabricated via chemical treatment method,were attributed by X-ray diffractometer（XRD） and surface contact angle measuring instrument. Then according to GB/T16886.4-2003 Bioogical evaluation of medical devices-Part 4:Selection of tests for interactions with blood,the hemocompatibilities of Ti-15Mo-3Nb and K₂Ti_nO_2n+1 bioogical film/Ti alloy biomaterials were contrastively evaluated by the dynamic blood-clotting tests,haemolysis ratio measurement and platelet adhesion tests.The interaction mechanics between materials and blood were preliminarily discussed from the angles of composition and surface energy of K₂Ti_nO_2n+1 bioogical film.The results clearly indicated that K₂Ti_nO_2n+1 bioogical film had more excellent hemocompatibility than Ti-15Mo-3Nb alloy.And its hemo-compatibility had direct relations with its the surface chatacteristics.It was proved that K₂Ti_nO_2n+1 bioogical film was a novel biomaterial with application value.更多还原