【作者】 周星； 樊荣； 张文娟； 朱明； 梁建辉； 毛协民；

【Author】 ZHOU Xing1, FAN Rong1, ZHANG Wen-juan2, ZHU Ming2, LIANG Jian-hui3, MAO Xie-min1 (1.School of Materials Science & Engineering, Shanghai University, Shanghai 200072,China; 2. General Research Institute for Nonferrous Metals, Beijing 100088, China; 3. The Cecond People’s Hospital, Guangzhou Medical College, Guangzhou 510540, China)

【机构】 上海大学材料学院； 北京有色金属研究总院加工中心； 广州医学院第二附属医院；

【摘要】 针对人工食管用的TiNi形状记忆合金,实验研究了合金的细胞毒性,并用TiNi合金的加速降解方法模拟长期植入人体时的变化,对TiNi形状记忆合金的生物相容性进行了初步探索性研究。研究表明,从体外实验结果来看,TiNi合金具有良好的生物相容性,其降解产物符合细胞毒性要求,呈阴性。最后对TiNi形状记忆合金在人工食管中的临床应用进行了讨论,鉴于人体环境的复杂性,开发无镍形状记忆合金,将是形状记忆合金应用于人工食管的方向。更多还原

【Abstract】 The cytotoxicity of TiNi SMA alloy in the artificial esophagus were investigated in the paper. With an accelerated degradation method the variation of the human body embedding TiNi alloy as implant for long time was simulated. The preliminary exploratory research results show that TiNi SMA alloy has a good biologic compatibility. Its degradation product meets the necessity for cytotoxicity requirement and the cytotoxicity test appears negative. Finally the clinical application of the TiNi SMA Alloy in the artificial esophagus was discussed. In view of the complexity of human physical characteristics it is necessary to develop a SMA alloy without Ni content using in the artificial esophagus.更多还原