【作者】 宋宇； 鲍子平； 高祖禄； 宁安； 胡启龙； 陈名刚； 陈凡经； 葛军； 肖树华； 周晓农； 徐晶；

【Author】 Song Yu~1,Zhou Xiao-nong~2,Gao Zu-lu~1,Hu Qi-long~1,Bao Zi-ping~2,Nin An~2, Chen Ming-gang~2,Chen Fan-jing~1,Xu Jing~1,Xiao Shu-hua~2 (1 JiangxiProvincialIinstitute of ParasiticDiseases,Nanchang 330046,China)

【机构】 江西省寄生虫病研究所； 中国疾病预防控制中心寄生虫病预防控制所； 南矶乡卫生院；

【摘要】 目的观察江西省新建县湖区南矶乡血吸虫病重度流行区用蒿甲醚预防日本血吸虫感染的效果。方法 2004年5月～11月,以南矶乡的南山岛为试点,居民以半农半渔为业,选择6～65岁居民随机分为蒿甲醚一组、蒿甲醚二组和对照组。在服蒿甲醚前30天,经粪便血吸虫卵检查后,全民服单剂吡喹酮40mg/kg治疗。蒿甲醚一组每半个月服一次蒿甲醚6mg/kg,共13次;蒿甲醚二组每个月服一次蒿甲醚6mg/kg,共7次;对照组服相同剂量的安慰剂。全程用双盲法进行粪检、服药和观察。末次服药后40～60天作粪检复查。结果蒿甲醚一组413例的粪检虫卵阳性率为3.4%,明显低于对照组587例粪检的虫卵阳性率13.5%,保护率为74.8%;蒿甲醚二组402例粪检的感染率为10.5%,与对照组的差别不显著。结论在血吸虫病传播季节,每半个月服1次蒿甲醚6mg/kg,对湖区重度流行区人群有较好的预防效果,而每月服一次蒿甲醚的预防效果差。更多还原

【Abstract】 Objective To study the effect of artemether(Art) in protection of the residents from infection with Schistosoma japonicum in a heavily endemic area of Nanji Township located in the Poyang Lake.Methods Nansan islet in Nanji Township was selected as the pilot of the study where most of the residents engaged in semi-agriculture and semi-fishery. From May to November,2004,the residents aged 6-65 years in the pilot were selected for the study and allocated randomly to ArtⅠgroup,ArtⅡgroup and the control group.One month before performance of prevention with Art,all the residents were treated orally with praziquantel at a single dose of 40 mg/kg post stool examination.In ArtⅠgroup,me first dose of 6 mg/kg was given to the residents in late May,followed by repeated dosing every 15 days for 13 doses.In ArtⅡgroup,the same dose of Art was given monthly for 7 doses.Placebo(starch,6 mg/kg) was given to the residents in the control group at the same time as in Art I group.The efficacy was evaluated by stool examination 40-60 days post the last medication.Double blind method was used in stool examination,administration of the drug and observation.Results In Art I group,14 out of 413 residents examined revealed stool positive with an egg-positive rate of 3.4%,while in the control group,79 out of 587 residents showed stool positive with egg-positive rate of 13.5%.The difference between the two groups was statistically significant with protection rate of 74.8%.In Art II group,42 out of 402 residents revealed stool positive with egg-positive rate of 10.5%which exhibited no significant difference compared with the control group.Conclusion In heavily endemic area of schistosomiasis,oral Art given every 15 days during the whole transmission season exhibited a promising preventive effect.But much less effect was seen,when Art was given monthly.更多还原