【作者】 李乐军； 陶美华； 陈玉婵； 郑彩霞； 霍光华； 章卫民；

【Author】 LILe-Jun~(1,2) TAO Mei-Hua~2 CHEN Yu-Chan~2 ZHENG Cai-Xia~3 HUO Guang-Hua~(1*) ZHANG Wei-Min~(2*) 1 College of Bioscience and BioengineeringJiangxi Agricultural University;Nanchang Key Laboratory of Bioresource Conservation and Utilization,Nanchang,Jiangxi 330045,China,2 State Key Laboratory of Applied Microbiology,South China(The Ministry—Province Joint Development);Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application;Guangdong Open Laboratory of Applied Microbiology;Guangdong Institute of Microbiology,Guangzhou,Guangdong 510070,China,3 College of Pharmacy,Guangdong Pharmaceutical University.Guangzhou,Guangdong 510006,China

【机构】 江西农业大学生物科学与工程学院 南昌市生物资源保护和利用重点实验室； 广东省微生物研究所省部共建华南应用微生物国家重点实验室 广东省菌种保藏与应用重点实验室 广东省微生物应用新技术公共实验室； 广东省微生物研究所 省部共建华南应用微生物国家重点实验室 广东省菌种保藏与应用重点实验室 广东省微生物应用新技术公共实验室； 广东药学院药科学院；

【摘要】 采用硅胶柱、反相硅胶柱、凝胶柱、薄层制备和HPLC等色谱技术对1株分离自南海沉积物的海洋真菌菌核青霉Penicillium sclerotiorum FS50的大米发酵提取物进行分离纯化,从中分离得到7个化合物。通过波谱数据分析,化合物1-7分别被鉴定为:butyl 6,8-dihydroxy-1-oxo-1H-isochromene-3-carboxylate(1),6,8-dihydroxyisocoumarin-3-carboxylic acid(2),3-carboxy-8-hydroxy-6-methoxy-1-oxo-1 H-2-benzopyran(3),(+)-sclerotiorin(4),4-methyl-5,6-dihydropyren-2-one(5),5-羟甲基糠醛(6),胡萝卜甙(7)。化合物1为新化合物,化合物2,3,6为首次从青霉属中分离得到。更多还原

【Abstract】 Seven compounds were isolated from the extract of the marine fungal strain of Penicillium sclerotiorum FS50 fermented on rice by Various chromatographic methods such as sillica gel,reverse sillica gel,Sephadex LH-20,preparative TLC and HPLC.Their structures were determined as butyl 6, 8-dihydroxy-l-oxo-lH-isochromene-3-carboxylate(1),6,8-dihydroxyisocoumarin-3-carboxylic acid(2), 3-carboxy-8-hydroxy-6-methoxy-1 -oxo-1 H-2-benzopyran(3), (+)-sclerotiorin(4),4-methyl-5,6-dihydropyren-2-one(5),5-hydroxymethylfurfural(6),daucosterol(7) by extensive analysis of the spectroscopic data.Compound 1 was identified as a new compound,and compounds 2,3 and 6 were isolated for the first time from Penicillium.更多还原