【作者】 周霞萍； 张义超； 张世万； 班卫静； 余文凤；

【Author】 Zhou Xiaping,Zhang Yichao,Zhang Shiwan,Ban Weijing,Yu Wenfeng (East China University of Science and Technology,Shanghai,200237)

【机构】 华东理工大学；

【摘要】 腐植酸属于生物大分子,自《本草纲目》记载"乌金散"(腐植酸)作为药物应用已有500多年的历史。近30年来,中国数十家医疗单位和大专院校对腐植酸进行了正规的临床试验和毒理学、药理学研究。德国、波兰、瑞士、芬兰等医学家也进行过类似研究,肯定了腐植酸具有活血止血、抗菌、抗病毒、改善微循环、调节内分泌等作用,相当于中草药扶正驱邪、协调阴阳、补偏救弊的功效。作为生物大分子,腐植酸的药理研究虽较薄弱,但仍有迹可循。作为药物,在药典中如何开好处方?这是影响腐植酸医药研究进展的关键问题。作者认为,先采用低碳生物降解法减小腐植酸分子的复杂性,再按腐植酸活性组分、药理药效、确定适用范围,可逐步克服腐植酸医学应用的瓶颈问题,加快腐植酸医药研究的进展。更多还原

【Abstract】 Humic acids are biological macromolecules.It has been 500 years since"WU-JTN-SAN"(i.e.humic acid) reported in Compendium of Materia Medica.In recent 30 years tens of medical companies and institutions have done regular clinical trials,toxicological and pharmacological research on humic acids.Besides,German,Polish,Swiss, Finland et al.have also done similar research,with the similar efficacy of Chinese herbal medicine like"Streagthening Vital Qi’s Capacity to Resist Pathogens","Readjusting Yin and Yang","remedy defects and rectify errors"which build a scientific fundament for medical application of humic acid.As biological macromolecules,although humic acid was relatively weak in pharmacological studies,it was still traceable.As a drug,how to make a prescription in the pharmacopoeia? This is the key issues which affect the progress in humic medical research.The author consider:First,the use of low-carbon biodegradation reduces the complexity of humic acid molecules,then acoording to the active component by humic acid,Pharmacological-pharmacodynamic,and determining the scope of medical applications could gradually overcome the bottleneck of medical research in humic acid,accelerat the progress of medical research of humic acid.更多还原