【作者】 祝仕清； 牛长群；

【Author】 ZHU Shi-qing,NIU Chang-qun (Research & Development Drug Center,North China Pharmaceutical Corporation,Shijiazhuang 050015,China)

【机构】 华北制药集团新药研究开发中心；

【摘要】 <正>随着抗生素在临床上的广泛使用,及各种耐药菌的不断出现,细菌的耐药性问题逐渐成为关注的热点及研究的难点。糖肽类抗生素,尤其以万古霉素和替考拉宁为代表的抗生素,有效地解决了细菌耐药问题,成为抗耐药性感染的最后一道防线。更多还原

【Abstract】 LC-MS and LC-MS/MS methods were established to identify the main components of teicoplanin. By using electrospray ionization and positive ion monitoring,mass spectrometric detection were operated on a sigle quadrupole mass spectrometer and a triple quadrupole tandem mass spectrometer.Six components of teicoplanin were identified and determined.The established methods can be used to analyze teicoplanin qualitatively and quantitatively in the new drug development for quality control and stability study.更多还原