恐怖音乐触发脑内快速的单胺类受体改变

【作者】 张莺； 陈巧珍； 杜锋磊； 胡燕妮； 曹芳芳； 田梅； 张宏；

【机构】 浙江大学医学院附属第二医院核医学科； 浙江大学医学PET中心； 浙江大学核医学与分子影像研究所 浙江省医学分子影像重点实验室；

【摘要】 目的:恐怖音乐可以快速引起听者类似真实的威胁生命经历的情绪变化,然而通过音乐研究相关情绪变化发生机制的报道非常有限,本研究通过11C-NMSP PET(正电子发射端茶扫描)脑图像观察脑内单胺类受体在恐怖音乐刺激下的改变情况。方法:10名年龄匹配的正常男性志愿者纳入此项研究,同时我们记录下来听音乐同时志愿者的心理生理改变情况。结果:研究结果发现志愿者在听音乐和基础状态相比,11C-NMSP在双侧尾状核、右侧边缘和旁边缘脑区,尤其在右侧前扣带回皮质明显减低;同时11C-NMSP在右侧额叶、枕叶、左侧颞叶明显增加。结论:我们的研究结果表明恐怖音乐引起的短暂的恐怖情绪可以引发脑内单胺类受体的迅速改变。这个研究结果对于我们理解大脑恐怖机制有所帮助。更多还原

【Abstract】 Frightening music can rapidly arouse emotions in listeners that mimic those from real life-threatening experiences. However,the study on the underlying mechanism for perceiving danger created by music is very limited.Methods: We investigated monoamine receptor changes induced by frightening music using the 11C-NMSP positron emission tomography(PET) study.Ten male,healthy volunteers were included,and their psychophysiological changes were evaluated.Results:The radioactive accumulations of 11C-NMSP were significantly decreased in the bilateral caudate,right limbic and paralimbic regions,especially in the right anterior cingulated cortex,but were increased in the cerebral cortex involving right frontal,occipital lobe and left temporal lobe when subjects had listened to frightening music,compared to a baseline condition. Conclusion:Our results indicate that transient fear emotion in response to frightening music can trigger rapid change monoamine receptors.These findings help to understand the mechanism of brain response to fear emotion.更多还原