【作者】 孟祥才； 王静； 魏宇宏；

【Author】 MENG Xiangcai,WANG Jing,WEI Yu-hong 1.Provincial Key Laboratory of Biomaterials,Jiamusi University,Jiamusi Heilongjiang Province China 154007 2.Ning Le Construction Engineering Measuring Ltd,Ningbo Zhejiang Province China 315006

【机构】 佳木斯大学,省生物材料重点实验室； 宁波市宁乐建筑工程检测有限公司；

【摘要】 目的:以丝素（silk fibroin,SF）为模板调控羟基磷灰石（hydroxapatite,HA）的结构和形貌,获得具有天然骨结构的纳米羟基磷灰石,为生物材料的制备提供新方法。方法:利用丝素溶于氯化钙的特性,以其为钙源在CaCl₂和（NH₄）₂HPO₄体系中制得纳米羟基磷灰石,借助XRD、DSC-TG、FTIR技术对其结构和形貌进行表征,分析讨论合成过程、机理和影响因素。结果:丝素可以有效调控HA的结构和形貌,丝素的存在提高了HA的结晶度、在（002）方向具有择优取向生长;合成机理为HA在SF活性基团上成核。结论:仿生合成的HA/SF材料有望成为具有发展潜力的骨组织工程材料。更多还原

【Abstract】 Objective To obtain nano-hydroxyapatite similar to the natural bone structure by silk fibroin as template and provide new method for the preparation of biological materials.Method: Nano-hydroxyapatite/silk fibroin composites（HA/SF） were obtained from the CaCl₂ and（NH₄）₂HPO₄ system using the characteristics of silk fibroin dissolved in calcium chloride as calcium source,its structure and morphology were characterized using XRD,DSC-TG,FTIR technology,synthetic mechanism was analyzed and influencing factors were discussed.Results:Fibroin could effectively regulated the structure and morphology of HA,the presence of silk fibroin increased the crystallinity of HA with a preferred orientation growth along（002） direction;synthesis mechanism for the HA was that HA nucleated on active groups of SF.Conclusion:HA/SF material of biomimetic synthesis is a promising bone tissue engineering materials.更多还原