【作者】 李洪波； 王燕玲； 郑菁； 王延才； 黄大鸿； 梁丽萍； 任旭东； 窦瑜贵； 朱小南；

【Author】 LI Hongbo,WANG Yanling,ZHENG Jing,WANG Yancai,HUANG Dahong,LIANG Liping,REN Xudong,DOU Yugui,ZHU Xiaonan Gansu Centre for Disease of Control and Prevention,Lanzhou 730020,China

【机构】 甘肃省疾病预防控制中心； 武威市疾病预防控制中心；

【摘要】 目的了解不同妊娠期妇女碘营养水平及甲状腺功能状态。方法于2009年4月-2010年1月采用横断面调查方法随机抽取甘肃省武威市90名(城市49人,农村41人)妊娠期妇女。采集样本人群空腹晨起血样及任意一次尿样,检测血清促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺激素(FT4)、甲状腺球蛋白抗体(TGAb)、甲状腺微粒体抗体(TMAb)及尿碘。结果孕早、中、晚期妇女尿碘中位数分别为231.49、158.25和328.35μg/L,尿碘低于150μg/L的比率分别为39.29%、45.16%、25.81%。孕早期FT3、FT4水平高于孕晚期(P﹤0.05),TSH水平呈增高趋势,组间比较差异无显著性(P>0.05)。不同妊娠期妇女TGAb、TMAb抗体阳性率比较差异无显著性(P>0.05)。孕早、中、晚期妇女甲状腺功能紊乱发生率比较差异有显著性(P<0.05)。结论妊娠妇女碘营养状况良好,部分孕妇存在甲状腺功能减退倾向。更多还原

【Abstract】 Objective To investigate the iodine nutritional status and thyroid function of pregnant women during different periods of pregnancy,to provide evidence for guiding iodine supplementation for them.Methods A cross-sectional survey was performed in 90 pregnant women in Wuwei City from April 2009 to January 2010.The morning blood samples and random urine samples were collected,and the thyroid-stimulating hormone(TSH),free triiodothyronine(FT3),free thyroid hormone(FT4),thyroglobulin antibodies(TGAb),thyroid microsomal antibodies(TMAb) in blood samples and iodine in urine samples were detected.Results The medians of urinary iodine were 231.49,158.25 and 328.35μg /L for women in early,middle and late period of pregnancy,The ratio of urinary iodine below 150μg /L were 39.29%,45.16% and 25.81%,respectively.The FT3,FT4 levels in the first trimester were higher than those in the third trimester(P < 0.05) and TSH level was increased,but no significant difference(P > 0.05).The positive rate of TGAb and TMAb antibody of pregnant women in different period of time were not significantly different(P > 0.05).The incidence of thyroid function disorder was significantly different in different gestation periods.Conclusion Generally,the iodine nutritional status of these pregnant women was appropriate,but there was a tendency towards hypothyroid in some women.Monitoring urinary iodine and thyroid function in pregnant women should be carried out regularly.更多还原