【作者】 赵长峰； 刘岩； 胡藩； 于连龙； 王政； 张丙银； 孙文魁；

【Author】 Zhao Changfeng Liu Yan Hu Fan Yu Lianlong Wang Zheng Zhang Bingyin Sun Wenkui (1 Department of Nutrition and Food Hygiene,School of Public Health,Shandong University,Jinan 250012,China; 2 Tianrui Nutrition Intervention Center of Chronic Disease,Jinan 250013,China)

【机构】 山东大学公共卫生学院营养与食品卫生学研究所； 天瑞慢病营养干预中心；

【摘要】 目的通过科学指导和持续督促超重或肥胖的Ⅱ型糖尿病患者减轻体重,探索短期体重干预对其体内糖脂代谢的影响。方法采用健康管理模式和自身对照流行病学研究方法,对济南市116例超重或肥胖的Ⅱ型糖尿病患者实施45天的体重干预,即配制控制能量的营养早餐,指导中餐和晚餐合理饮食,定时做运动体操等健身活动,并在干预前后分别抽血检测血糖、血脂,同时测量身体各项指标。结果研究对象中有90例Ⅱ型糖尿病患者依从性良好;与干预前比较,干预后患者的空腹血糖(FBG)和餐后2小时血糖水平、体重、BMI、腰围、臀围和上臂围值均有显著性下降(P<0.05);但血清TC、HDL-C、LDL-C水平均有显著性升高(P<0.05);腰臀比、体脂含量及血清TG水平变化不明显。结论对Ⅱ型糖尿病患者进行健康管理体重干预时,短期内其血脂代谢具有特殊性,部分血脂项目会升高,需要密切监测与控制,以防促发心血管病变。更多还原

【Abstract】 Objective To explore how health management of short-term weight intervention affects glycolipid metabolism of patients with type Ⅱ diabetes by scientific guiding and sustained supervising them losing weight.Methods 116 overweight or obese type Ⅱ diabetes mellitus patients in Ji’ nan were under weight intervention for 45 days with health management model and the epidemiologic method of self control.They were provided with nutritional breakfast, guided to have the other two meals in the right way,and asked to do sports regularlyTheir blood sugar,blood lipid and the body measurement data were recorded before and after the intervention.Results 90 patients with type Ⅱ diabetes of the subjects were of good obedience.Compared with before intervention,the levels of both fasting blood-glucose (FBG)and blood-glucose 2 hours after meal,weight,BMI,waistline,hip circumference and upper arm circumference of the patients after intervention lowered significantly(P<0.05);levels of serum TC,HDL-C,LDL-C elevated obviously(P<0.05);and their waist-to-hipratio,body fat content and TG levels did not change significantly. Conclusions Due to the particularities of their blood lipid metabolism mentioned above such as that certain serum lipid levels may increase,when carrying out health management of short-term weight intervention on patients with type Ⅱ diabetes,their blood lipid metabolism should be monitored and observed closely to avoid cardiovascular disease.更多还原