【作者】 苗蕾； 姚华； 孙玉萍； 李莉； 伊惠霞；

【Author】 MIAO Lei~1 YAO Hua~2 SUN Yu-ping~3 et al. (Xinjiang Medical University,Urumqi;The First Teaching Hospital of Xinjiang Medical University,Urumqi 830011,China)

【机构】 新疆医科大学公共卫生学院； 新疆医科大学第一附属医院； 新疆医科大学基础医学院；

【摘要】 目的研究新疆地区维吾尔族人群血清脂联素水平与高尿酸血症的相关性。方法用ELASA酶联免疫法测定413例研究对象的血清脂联素,血清检测血尿酸(SUA)及血脂等相关生化指标。结果维吾尔族高尿酸组与对照组的腰围、臀围、腰高比(WHTR)、甘油三脂(TG)及脂联素的差异均有统计学意义,其中高尿酸组血清脂联素水平显著低于对照组(P<0.01)。在扣除了体脂因素后脂联素在两组间的差异仍然存在(P<0.01),且在正常对照人群中,女性脂联素水平显著高于男性(P<0.01)。脂联素与SUA之间存在负相关,与年龄无相关性。结论脂联素作为脂肪细胞分泌的特异性蛋白,其与SUA的相关性提示脂联素可能是高尿酸血症发生的特征性指标之一,为维吾尔族高尿酸血症的防治提供依据。更多还原

【Abstract】 Objective To investigate the relationships between serum adiponectin concentration and hyperuricemia on Uygur in Xinjiang.Methods The serum adiponectin concentration was measured in 413 cases(207 cases were in hyperuricemia group and 206 cases were in control group)by ELASA and measured SUA、TG、TC、HDL-C、LDL-C、height、body weigh、waist circumference(WC)、hip circumference(HC)、,then calculated waist-toheight ratio(WHTR)、body mass index(BMI).Results The WC、HC、WHTR、TG levels were significantly increased in hyperuricemia group compared with control group.Levels of adiponectin in hyperuricemia group were significantly lower than those in the control group(P<0.01).The difference between two groups still exist after the adjustment of body fat.In control group,the level of adiponectin in female were significantly higher than those in male (P<0.01).The serum adiponectin concentration was significantly negatively correlated with SUA.But adiponectin was not significantly correlated with age.Conclusion The strong correlation between adiponectin and SUA suggests a possibility that adiponectin might be one of the characteristic index of hyperuricemia in Uygur.更多还原