【作者】 孙长颢； 李颖； 刘荣； 孙敏； 崔文秀；

【Author】 Sun Qianghao,Li Ying,Liu Rong,Sun Min,et al. Department of Nutrition and Food Hygiene,Public Health College,Harbin Medical University,Harbin 150001,China

【机构】 哈尔滨医科大学公共卫生学院； 哈尔滨市中山路小学； 哈尔滨市卫生防疫站；

【摘要】 为研究瘦素在女性从青春期前到整个青春期发育过程中作用,及瘦素、雌二醇和睾酮在此过程中的变化规律和相互关系,检测7～17岁不同营养状况(150名肥胖、150名正常和150名营养不良)女性血中瘦素、雌二醇和睾酮水平,并调查了月经初潮时间。结果显示7～17岁女性瘦素变化规律:逐渐升高~→出现第个高峰(肥胖组、正常组和营养不良组峰值分别为14.46μg/ml;8.85μg/ml;8.60μg/ml)~→下降~→出现突增(第二高峰)~→突降(13～,P<0.01)~→缓慢上升~→下降的趋势;不同营养状况女性瘦素突增时间不同,第高峰与青春期发育开始时间相致,第二高峰出现在青春期后期。三组雌二醇水平从11岁开始迅速增长,并随年龄的增长而升高,瘦素与雌二醇无相关性。三组睾酮在10岁均出现增长高峰,之后下降,在12岁均出现迅速升高。瘦素与睾酮无相关性。提示瘦素可能是调控女性青春期发育过程的决定因素,瘦素第增长高峰可能是青春期启动信号,第二增长高峰可能是青春期结束信号。更多还原

【Abstract】 To study the changing regularity of leptin during puberty in girls and the relationship of leptin,estradiol and testosterone each other,serum levels of leptin,estradiol（E₂） and testosterone（T） were deta-mined in blood in 150 obese girls,150 normal girls and 150 malnourished girls,aged from 7 to 17 years old.Their ages of menarche were surveyed. The results showed that serum levels of leptin increased with age,and had double peaks.The first peak of leptin was found during the early phase of puberty in all groups.The value of peak were 14.46μg(ml,8.85μml,8.60μg/ ml in obese, normal and malnourished groups respectively.The second peak of leptin emerged at the end of puberty in the three groups. The level of E₂ increased sharply at the eleven years old in three groups,then increased progressively with age.Serum level of E₂ did not correlated with leptin.There was a peak level of T at 10 years old in obese groups,as well as normal and malnourished groups.The level ofT emerged rised sharply at 12 years old after a decrease in all groups.Serum level of T did not correlated with lertin.It is suggested that leptin may be a more important decisive factor during pubertal development course in girls.The first peak of leptin may be the signal of onset of puberty.The second peak of leptin may be the signal of the end of puberty.更多还原