【作者】 薛琨； 郭红卫； 陈凤麟；

【Author】 Xue Kun,Guo Hong wei,Chen Feng- lin School of Public Health,Fudan University,Shanghai 200032,China

【机构】 复旦大学公共卫生学院营养与食品卫生教研室；

【摘要】 目的研究中链脂肪酸(MCFA)对营养性肥胖大鼠体重、体脂和血脂水平的影响。方法采用预防肥胖模型法,每天给予SD大鼠高脂营养饲料,并灌胃含不同剂量MCFA的食用油脂,饲养38天,观察体重、摄食量、体脂重量、血脂、胰岛素水平在不同剂量组动物间的差异。结果高、中、低三个刊量组大鼠分别摄入0.975、0.325和0.163g/bg bw MCFA38天,高剂量组与模型对照组相比,体重明显较低[分别(295.2±29.7)g和(324 6±9.1)g](P<0.05),脂肪垫重量明显较轻[分别(5.30±1.57)g和(7.20±1.74)g](P<0.05),脂肪细胞明显较小;各剂量组总的摄食量不显著低于模型对照组;血清甘油三酯(TG)、总胆固醇(TC)、胰岛素水平与模型对照组比较差异无显著性,中、高剂量组高密度脂蛋白胆固醇(HDL-C)水平高于模型对照组[分别(0.71±0.11)mmol/L、(0.73±0.12)mmol/ L、(0.60±0.06)mmol/L](P<0.05),高剂量组大鼠的瘦素水平显著低于模型对照组[分别(1.61±0.39)ng/ml和(2.04±0.46)ng/ml](P<0.05)。结论在饲料摄入量没有差别的前提下,摄入0.975g/kg MCFA对营养性肥胖大鼠的体重增长有一定抑制作用,对血脂水平没有不良影响。更多还原

【Abstract】 Objective Same researchers considered medium chain fatty acids a group of potential agents in the prevention of obesity for their particular metabolism characters.Methods In this study,the authors investigated the effects of medium chain fatty acids on body weight gains,food intake,adipose depots and serum lipid prrfiles.Healtiiy male Sprague Dawley rats were fed for 38 days with over-fat diets and oils containing MCFA at different level.Results Significant decreases of body weight[(295.2±29.7) g vs(324.6±9 1) g](P<0.05),the weight of adipose pads [(5.30+1.57) g vs(7.20+1.74)g](P<0.05),the level of leptin in serum[(1.61 +0.39) ng/ml vs(2 04+0 46) ng/ml](P<0.05),the sizes of fat cells but increase of HDL-C[(0.73 + 0.12)mmol/L vs(0.60±0.06) mmol/L](P<0.05) were noted in the group fed MCFA at 0.975g/kg bw per day as compared with those of the group fed soybean oil. Conclusion The results suggested the role of MCFA in prevention of obesity and there is no adverse effect on lipid metabolism if the proportion of MCFA to total fat scouce is mild.更多还原