【作者】 郑艳燕； 李习艺； 谢云峰； 袁秀玲； 肖德强； 郭松超；

【Author】 Zheng Yanyan,Li Xiyi,Xie Yunfeng,Yuan Xiuling,et al. School of Public Health,Guangxi Medical University,Nanning 530021,China

【机构】 广西医科大学公共卫生学院； 广西医科大学基础医学院化学教研室；

【摘要】 为研究缺铁性贫血(IDA)对大鼠的生殖机能及对仔鼠生长发育影响,将4周龄Wistar雌性大鼠随机分为二组,实验组喂低铁基础饲料,对照组喂在基础饲料中添加铁的对照饲料。14周后与正常雄鼠合笼交配,观察仔鼠的生长发育情况。对母鼠及仔鼠血清微量元素Fe、Zn、Cu、Mn、Se进行测定。结果显示,IDA组母鼠窝仔均数、活产率、活胎数及幼仔4日存活率均低于对照组(P<0.01);IDA组仔鼠出生体重低、生长迟缓、毛发稀疏,具典型贫血临床特征。;IDA组仔鼠血液指标检测:血红蛋白、红细胞压积均低于对照组(P<0.0001)。母鼠及仔鼠血清Fe、Cu低于对照组(P<0.0001)。结论认为缺铁性贫血可降低大鼠的生殖机能.严重地影响了仔鼠的正常生长发育,并导致仔鼠体内其它微量元素代谢失调。更多还原

【Abstract】 The effects of iron deficiency anemia(IDA) on the reproduction of female rats and the development of their offspring were studied.Four week old female Wistar rats were randomly divided into two groups.The rats in experimental group and control group were fed on low iron or normal diet respectively for 14 weeks,and then they were mated with normal adult male rats.The development and growth of the newborn,weanling and four day old offspring was observed and the trace element Fe,Zn,Cu,Mn and Se in serum were measured.IDA male notable impacts on the reproduction of female rats with small sized litters,less living fetal rats.The survival rate of female rats in the IDA group was less than that in control group.Hemoglobin and packed cell volume in blood were lower in IDA group than those in control group(P< 0.0001).The content of serum Fe and Cu in IDA group was also lower than that in control group.Iron deficiency might cause metabolism disorders of other trace element.更多还原