【作者】 王舒然； 于春媛； 孙长颢； 刘志芳； 张薇； 付荣霞；

【Author】 Wang Shuran,Yu Chunyuan,Sun Changhao,Liu Zhifang,et al. School of Public Health,Harbin Medical University,Harbin 150001,China

【机构】 哈尔滨医科大学公共卫生学院；

【摘要】 为研究儿童青春期血液中瘦素、生长激素和胰岛素水平的变化规律及其相关性,分别检测了10～15岁300名单纯性肥胖儿童与300名正常儿童血中的瘦素、生长激素和胰岛素水平。结果随着年龄的增长,瘦素水平在男童中呈现低→高→低的变化规律,在女童中呈现逐渐增高趋势;生长激素水平在某一年龄段突增(男童:14～15岁,女童:13～14岁);胰岛素水平的变化无明显规律。各年龄段肥胖儿童血瘦素和胰岛素水平均显著高于正常儿童(P<0.01);各年龄段肥胖男童生长激素水平明显低于正常男童(P<0.01)。男童中生长激素与瘦素呈负相关(肥胖组:r=-0.74,P<0.05;正常组:r=-0.69,P<0.05),在女童中生长激素与瘦素呈正相关(肥胖组:r=0.58,P<0.05;正常组:r=0.67,P<0.01)在正常女童中胰岛素与瘦素呈正相关(r=0.54,P<0,05)。提示在儿童青春期的启动过程中,瘦素可能发挥了重要作用,并且在女童青春发育期中的作用比在男童更为重要;瘦素与生长激素相关性在两性的差异可能是造成男女儿童生长突增时间不同的原因之一。更多还原

【Abstract】 In order to study the regularity of changing leptin,growth hormone(GH) and insulin(INS) during puberty and their relationships,a group of 300 obese and 300 non-obese children,aged 10-15 were selected.Leptin level increased with age and then decreased in boys,but it had only increasing tendency in girls.The GH level increased and then decreased suddenly in all groups.There was no obvious regularity in the change of INS.Serum leptin and INS levels were higher(P< 0.01) in obese children than that in non-obese children,while GH levels were significantly lower(P< 0.01) in obese boys.Results also showed that GH was negatively correlated with leptin in boys(obese group:r=-0.74,P< 0.05;non-obese group:r=-0.69,P< 0.05) and positively correlated with leptin in girls(obese group:r= 0.58,P < 0.05;non-obese group:r= 0.67,P < 0.01).There was a positive correlation between INS and leptin in non-obese girls(r=0.54,P< 0.05).It is concluded that leptin might play an important role during the initial stage of puberty in children and the effect of leptin on pubescent development in girls is greater am pared with boys.The correlation between leptin and GH are gender dependent in boys and girls,which may cause the timing differences of sudden growth in boys and girls.更多还原