【作者】 马爱国； 徐宏伟； 杜卫； 刘颖；

【Author】 Ma Aiguo,Xu Hongwei,Du Wei,Liu Ying Institute of Human Nutrition,Qingdao Medical College,Qingdao University,Qingdao 266021,China

【机构】 青岛大学医学院营养研究所；

【摘要】 为观察维生素A与维生素E能否增强叶酸的防畸效果,采用环磷酰胺致大鼠胎鼠发育畸形作为动物模型,孕鼠在孕期分别补充叶酸和叶酸+维生素A+维生素E,观察其防畸效果。结果显示孕鼠不补充叶酸和维生素、单独补充叶酸和联合补充叶酸、维生素A和维生素E使胎鼠脑膨出率分别为87.27%、42.03%和30.08%(P<0.01)。联合补充组与单独补充叶酸组相比,脑膨出率降低更为明显(P<0.05),上枕骨骨化程度明显提高(P<0.01),胎鼠平均体重增加(P<0 05)。结果提示叶酸、维生素A、维生素E有明显促进胚胎发育及拮抗环磷酰胺的致畸作用,且叶酸与维生素A、维生素E联合应用的作用明显优于单独补充叶酸。更多还原

【Abstract】 The effect of folic acid and the combined effect of folic acid(FA) + vitamin A+ vitamin E on the prevention of teratogenesis induced by cyclophosphamide during pregnancy were observed.The results showed that cyclophosphamide resulted a decreased weight and length of the fetuses,an increased rate of neural tube defects and a retardation of ossification centers.The neural tube defects rates in the groups with no any supplementation,supplemented with folic acid alone and supplemented with FA+ vitamin A+ vitamin E were 87.27%,42.93%and 30.08%respectively(P<0.01). The supplementation of FA or the combined supplementation resulted also in greater fetal weight and length,increased ossification of supraoccipital bone(P<0.01).The study suggested that the combined effect of FA,vitamin A and vitamin E was superior to FA alone.更多还原