【作者】 刘晓秋； 韩英； 沈秀； 赵阿津； 周则卫；

【Author】 LIU Xiaoqiu, HAN Ying, SHEN Xiu, ZHAO Ajin, ZHOU Zewei ( Institute of Radiation Medicine, Chinese Academy of Medical Sciences , Peking Union Medical College, Tianjin 300192, China)

【机构】 中国医学科学院中国协和医科大学放射医学研究所天津市分子核医学重点实验室；

【摘要】 目的:检测尼可胺的致突变性,为临床安全用药提供理论依据。方法:采用Ames试验、CHO细胞染色体畸变试验及小鼠微核试验。结果:Ames试验中加S9与不加S9混合液的各剂量组回变菌数与阴性对照比较无显著性差异,且无剂量-效应关系。小鼠骨髓细胞微核率及CHO细胞染色体畸变率与阴性对照组比较,也无显著性差异(P>0.05)。结论:在本实验条件下,尼可胺无致突变作用。更多还原

【Abstract】 Objective To study the genetic toxicity of NiKeAn. Methods the mutagenicity of NiKeAn was examined using Ames test, CHO cell chromosome aberration test and micronucleus test. Results No increase in the number of revertant colonies was found in the Ames test with and without S9 mixture. The micronucleus rates and chromosome aberration rates in all doses were not significantly different from the control group. Conclusion The mutagenicity of NiKeAn was not observed in this study.更多还原