【作者】 贺松； 张德纯； 程芳； 龚芳红； 郭亚楠；

【Author】 HE Song1,ZHANG De-chun1,CHENG Fang2,GONG Fang-hong1,GUO Ya-nan1 (1.Department of Pathogenic Biology,Molecular Medicine & Tumor Research Center,Chongqing Medical University,Chongqing 400016,China,2.Laboratory Animal Center,Xi’ an Jiaotong University School of Medicine,Xi’ an 710061,China )

【机构】 重庆医科大学分子医学与肿瘤研究中心病原生物学教研室； 西安交通大学医学院实验动物中心；

【摘要】 目的系统评价国内双歧杆菌制剂临床预防小儿继发性腹泻的效果。方法按照系统评价的要求检索CBMdisc、VIP、CNKI以及万方数据库等,获得18篇符合纳入标准的文献,共计患儿4050例,对其进行Meta分析,并评价Meta分析结果的稳定性和发表偏倚。结果异质性检验x2=34.60,P=0.007<0.05,采用随机效应模型进行Meta分析,合并RR=0.41,95%Cl为0.35～0.49,总体效应检验,Z=10.39,P<0.00001,具有统计学意义,固定效应模型RR值和95%Cl与随机效应模型完全一致,剔除小样本报道后的合并RR=0.42,95%Cl为0.35～0.50,与剔除前的结果基本一致,且本研究的发表偏倚得到了很好地控制。结论从现有的临床证据来看,双歧杆菌制剂能降低小儿继发性腹泻的发生率,对预防小儿继发性腹泻起到了满意的效果。更多还原

【Abstract】 Objective To explore the clinical effect of Bifid-preparations in prevention of secondary diarrhea in infants in China.Methods Eighteen studies contained 4050 secondary diarrhea patients consistent with the inclusion and exclusion standards were searched from CBMdisc,VIP,CNKI and WanFang database,and were analyzed synthetically by Metaanalysis. Then evaluated the stability of the result and recognized the publication bias. Results The statistic is equal to 34.60 and the value is equal to 0.007<0.05 in the heterogeneity test,so the random effect model is used for Meta-analysis.The overall effect Z=10.39,P<0.00001.The combined RR is equal to 0.41,and its 95%confidence interval is between 0.35 and 0.49,and this is identical with fixed effect model.After rejected small sample studies,the combined RR=0.42,95%CI 0.35 to 0.50,witch is basically coincident with the result before rejected.The publication bias of this study was controled perfectly. Conclusion Bifid-preparations could reduce the incidence rate of secondary diarrhea in infants according to the clinical eidence currently available.The effect of Bifid-preparations in prevention of secondary diarrhea in infants was very satisfying.更多还原