【作者】 王永丽； 梁建芳； 郑绘霞； 肖虹； 程彩霞； 李宁；

【Author】 Wang Yongli,Liang Jianfang,Zheng Huixia,et al. Department of Pathology,First Clinical Medical College,Shanxi Medical University

【机构】 山西医科大学第一临床医学院；

【摘要】 目的:探讨B7-H4在卵巢癌中的表达及其临床病理意义。方法:采用免疫组织化学染色PV6000法检测13例正常卵巢组织、20例卵巢良性上皮性肿瘤组织、20例卵巢交界性上皮性肿瘤组织、40例卵巢癌组织标本中B7-H4的表达,并对其中40例卵巢癌B7-H4的表达与年龄、组织学类型、病理分期、分级及淋巴转移和患者预后之间的关系进行统计学分析。结果:(1)B7-H4在正常卵巢组织、卵巢良性上皮性肿瘤、交界性上皮性肿瘤及卵巢癌组织中的阳性表达比例分别为7.7%(1/13)、20%(4/20)、60%(12/20)、90%(36/40),交界性及恶性标本阳性比例明显高于非恶性标本,差异有统计学意义(P<0.05)。(2)40例卵巢癌标本中浆液性癌、内膜样癌、透明细胞癌、黏液性癌的B7-H4蛋白阳性比例分别为23/23、3/3、6/6、4/8,黏液性癌的蛋白阳性比例明显低于前三组,差异有统计学意义(P<0.05)。(3)B7-H4在卵巢癌Ⅲ期～Ⅳ期的阳性表达率显著高于卵巢癌Ⅰ期～Ⅱ期,差异有统计学意义(P<0.05)。结论:(1)40例卵巢癌组织中B7-H4的表达与组织学类型、病理分期及预后相关,而与年龄、病理分级和淋巴结转移等无关。(2)B7-H4抑制了卵巢癌组织中肿瘤浸润淋巴细胞的功能,其有可能成为辅助卵巢癌诊治的新的靶目标。更多还原

【Abstract】 Objective:To evaluate the expression of B7-H4 in epithelial ovarian tumor and the relationship between B7-H4 expression and the clinicopathological variables.Methods:Archival tissue blocks from 93 epithelial ovarian tumor patients including 13 normal ovarian tissues,20 benign tumors,20 borderline tumors,23 serous carcinomas,3 endometrioid carciniomas,6 clear cell carcinomas and 8 mucinous carcinoma were evaluated by immunohistochemistry PV6000 for the expression of B7-H4,and to analyze their relationship with age,histology type,pathology stage,cell differentiation,lymphametastasis and patient prognosis.Results:(1)The expression of B7-H4 in 13 normal ovarian tissues,20 benign tumors,20 borderline tumors and 20 ovarian cancers was 7.7%(1/13),20%(4/20),60%(12/20),90%(36/40)respectively.The expression of B7-H4 was higher in ovarian cancer than in ovarian borderline tumor and benign tumor(P<0.05).(2)The expression of B7-H4 in 23 serous carcinomas,3 endometrioid carciniomas,6 clear cell carcinomas and 8 mucinous carcinoma was 23/23,3/3,6/6,4/8 respectively(P<0.05).(3)The expression of B7-H4 decreased significantly in stageⅠand of stageⅡovarian cancer,compared with that in stageⅢand stageⅣ.Conclusion:(1)The expression of B7-H4 is correlated with the tumor histology type,pathology stage and patient prognosis,independent of age,cell differentiation,lymphametastasis.(2)These results suggest that the expression of B7-H4 on tumor tissue may contribute to negative regulatory immunue responses against TILs in ovarian cancer.It may be a new target of diagnosis and/or treatment for ovarian cancer.更多还原