【作者】 易成新； 倪大虎； 吴家道； 杨剑波；

【Author】 Yi Cheng-xin,Ni Da-hu,Wu Jia-dao and Yang Jian-bo Rice Research Institute,Anhui Academy of Agncultural Sciences,Anhui Key Laboratory of rice genetics and breeding,Hefei 230031,Anhui,China

【机构】 安徽省农业科学院水稻研究所安徽省水稻遗传育种重点实验室；

【摘要】 对转Xa21基因大米进行了ICR小鼠、SD大鼠急性毒性试验和SD大鼠90天喂养试验。结果表明,大、小鼠经口给样LD₅₀>20g/kg体质量,转基因大米无毒副作用;90天喂养试验中,16、32、64g/kg体质量个剂量组的雌、雄大鼠体重增加、食物利用率、血常规、血液生化指标、脏体比等各项指标与相应非转基因大米组以及普通饲料组相比均无显著性差异。初步证明转Xa21基因大米对大、小鼠是安全的。更多还原

【Abstract】 Using transgenic rice harboring Xa21 gene,toxicity experiments for ICR mice and SD rats, and 90-day feeding tests for SD rats were conducted.The results showed that oral LD₅₀ for ICR mice and SD rats was larger than 20g/kg and no toxicity was found.The SD rat groups fcd with 16,32,64g/kg-dosagc of transgenic rice had good development in 90-day feeding test.No obvious differences were found in the index of weight,food utilization rate,routine blood lest,items of blood biochemistry and ratio of organ to body（weight to weight） among the SD rat groups fed with the same dosage of transgenic and non-transgenic rice grain.It could be concluded that Xa21 transgenic rice is safe to the ICR mice and SD rats.更多还原