【作者】 谭宁； 李晓艳； 吴莹；

【Author】 Tan Ning, Li Xiaoyan, Wu Ying ( State Key Laboratory for Strength and Vibration / center for mechanical experimental teaching, Xi’an Jiaotong University, Xi’an 710049, China )

【机构】 西安交通大学强度与振动国家重点实验室/力学教学实验中心；

【摘要】 昼夜节律是生物系统动力学行为最显著的特征之一。果蝇是研究昼夜节律的优秀模式生物,PER和TIM是果蝇两个重要的生物钟蛋白。2006年Pablo Meyer等人的实验研究表明,PER-TIM复合物在细胞质中分离,然后PER和TIM分别独立进入细胞核。据此,我们对果蝇昼夜节律调控模型进行了修正,在此基础上讨论了温度对原模型及修正模型的影响。通过数值分析发现,无论在原模型还是修正模型中,mRNA的生成速率与降解速率、蛋白质的翻译后修饰对昼夜节律的影响较其他因素显著。然而,在修正模型中,PER-TIM复合物的累计速度对昼夜节律的影响显著;在原模型中,PER-TIM复合物的累计速度并没有对昼夜节律的周期产生显著影响。更多还原

【Abstract】 Circadian rhythm is one of the most remarkable characteristics of living systems. Drosophila is an excellent organism model for the study on circadian rhythm. PER and TIM are two important clock proteins in Drosophila. The experimental research, made by Pablo Meyer et al. in 2006, has indicated that PER-TIM complex dissociated in the cytoplasm then PER and TIM moved into the nucleus independently. In this paper we revise the circadian regulation network model of Drosophila according to this experimental result then we discuss the temperature effect on the original model and the revised model. By numerical analysis, it is found that, the influence of post-translational modification of proteins and the production rate and degradation rate of mRNA is more significant on the circadian rhythm than other factors both in the original model and the revised model. However, the PER-TIM complex cumulative speed shows more notable influence on the circadian rhythm in the revised model than the one in the original model.更多还原