【作者】 王睿； 黄远； 何芳； 王玉林； 万怡灶；

【Author】 Rui Wang,Yuan Huang,Fang He,RvlinWang,YizaoWan (School of Materials Science and Engineering,Tianjin University 30072)

【机构】 天津大学材料学院；

【摘要】 ε-聚赖氨酸(ε-PL)具有无毒性、抗菌性、生物可降解性,促进细胞生长和粘附以及促进细胞发挥正常功能的作用,近年来在生物材料的研究方面受到广泛关注。但其强度低、脆性大的特点限制了其在生物材料方面的应用。壳聚糖具有韧性强、黏度大、无毒、促进伤口愈合及极小的异体排斥作用,也是一种常用的生物材料。为了更好的满足生物材料的使用性能,本文首次制备了ε-聚赖氨酸/壳聚糖复合材料,并用戊二醛对其进行交联,以增强其宏观力学性能。本研究还对该复合材料进行了造孔实验,造孔的成功表明该复合材料具备应用于组织工程支架材料的性能及要求。红外图谱分析表明两种官能团发生了相互作用,X射线结果表明内部分子结构发生了变化,环境扫描电镜照片显示了复合材料的微观孔隙结构。更多还原

【Abstract】 Poly-ε-lysine(ε-PL)is nontoxic,biodegradable,and has the function of supporting attachment and growth of cell,thus,it has been taken notice in recent years for a broad range of applications as biomterials.However,the dominant limitations ofε-PL in applications as biomaterials are its relatively poor mechanical properties.Chitosan has also been shown to have wound healing properties,is nontoxic,and has minimal foreign body response with accelerated angiogenesis.It is one of good biomterials.For improving biological properties,we have preparedε-PL/chitosan composite materials.Then cross-linked by glutataldehyde in order to improve its mechanical properties.In this study,we fabricate porous structure and this indicate it is a promising candidate material for scaffold in Tissue Engineering.FTIR spectral analysis suggested that theε-PL/chitosan composite was prepared successfully.X-ray analysis indicated that the crystallinity ofε-PLL and composite material is different.SEM images showed the porous structure of the composite material.更多还原