【作者】 于洋；

【导师】 林琳；

【作者基本信息】 新疆医科大学 ， 妇产科学（专业学位）， 2025， 硕士

【摘要】 目的:探索不同身体质量指数(Body mass index,BMI)及伴有高雄激素的多囊卵巢综合征(Polycystic ovarian syndrome,PCOS)患者的脂质代谢特征,研究不同BMI及高雄激素对脂代谢的影响,为早期监测和临床管理PCOS患者的脂代谢性疾病提供思路。方法:按照2018年公布的《多囊卵巢综合征中国治疗指南》里规定的诊断规范,本研究选取了220例首次在新疆医科大学第一附属医院被确诊为PCOS的女性患者,一、根据BMI分为超重/肥胖组及体重正常组,二、根据是否伴有高雄激素分为高雄激素组及非高雄组,三、根据BMI及高雄激素分为高雄激素合并超重/肥胖组及其他组,四、根据血脂水平,将患者分为血脂异常组和血脂正常组。收集一般资料、内分泌激素及脂代谢指标资料,评估PCOS患者高雄激素及BMI与脂代谢的相关性。结果:(1)体重正常组与超重/肥胖组的PCOS患者在BMI、WC、WHR、FSH、LH/FSH、T、FPG、FINS、TG、HDL-C等指标上存在显著差异(P<0.05)。(2)PCOS患者高雄组与非高雄组LH、LH/FSH、T、E2、TC等指标上存在显著差异(P<0.05)。(3)高雄激素合并BMI≥24kg/㎡与其他组WC、HC、WHC、FPG、FINS、HOMA-IR、HDL-C、TG均存在显著差异(p<0.05)。(4)BMI的AUC值为0.672,腰围的AUC值为0.693,高雄激素的AUC值为0.822。结论:BMI、WC、高雄激素是血脂异常的独立危险因素,超重/肥胖及高雄激素加重PCOS患者的脂代谢异常。更多还原

【Abstract】 Objective:To explore the lipid metabolism characteristics of patients with polycystic ovary syndrome(PCOS)with different body mass index(BMI)and accompanied by hyperandrogenism,and to study the effects of different BMI and hyperandrogenism on lipid metabolism,providing ideas for the early monitoring and clinical management of lipid metabolic diseases in PCOS patients.Methods:According to the diagnostic criteria specified in the"Chinese Treatment Guidelines for Polycystic Ovary Syndrome"published in 2018,220 female patients who were first diagnosed with PCOS at the First Affiliated Hospital of Xinjiang Medical University were selected.They were divided into overweight/obese group and normal weight group based on BMI,hyperandrogenism group and non-hyperandrogenism group based on whether they were accompanied by hyperandrogenism,hyperandrogenism combined with BMI≥24 kg/m~2group and other groups based on BMI and hyperandrogenism,and dyslipidemia group and normal lipid group based on lipid levels.General information,endocrine hormone and lipid metabolism index data were collected to evaluate the correlation between hyperandrogenism and BMI with lipid metabolism in PCOS patients.Results:(1)There were significant differences in BMI,WC,WHR,FSH,LH/FSH,T,FPG,FINS,TG,HDL-C and other indicators between the normal weight group and the overweight/obese group of PCOS patients(P<0.05).(2)There were significant differences in LH,LH/FSH,T,E2,TC and other indicators between the hyperandrogenism group and the non-hyperandrogenism group of PCOS patients(P<0.05).(3)There were significant differences in BMI,WC,HC,WHC,FPG,FINS,HOMA-IR,HDL-C,TG between the hyperandrogenism combined with BMI≥24 kg/m~2group and other groups(p<0.05).(4)The AUC value of BMI was 0.672,the AUC value of WC was0.693,and the AUC value of hyperandrogenism was 0.822.Conclusion:BMI,WC,and hyperandrogenism are independent risk factors for dyslipidemia,and overweight/obesity and hyperandrogenism aggravate lipid metabolism disorders in PCOS patients..更多还原