【作者】 李华；

【导师】 朱鹏；

【作者基本信息】 重庆医科大学 ， 外科学（专业学位）， 2022， 硕士

【摘要】 目的:探讨腹腔热灌注化疗在阑尾黏液腺癌患者治疗中的临床价值。方法:收集重庆医科大学附属第二医院及重庆市南川区人民医院2014年01月至2020年03月术后病检为阑尾黏液腺癌的患者临床资料,共76例,术后均行静脉化疗,其中35例术后行静脉化疗的同时进行腹腔热灌注化疗(甲组);41例术后行静脉化疗未同时进行腹腔热灌注化疗(乙组)。对比甲、乙组术后腹腔内出血、感染、肠梗阻、吻合口漏、骨髓抑制并发症有无差异。随访两组病人术后半年、1年、2年复发率及生存率,总结腹腔热灌注化疗治疗阑尾黏液腺癌的临床价值。结果:甲组患者术后肿瘤复发率低于乙组、总生存率大于乙组,统计学差异(P<0.05);甲组比较乙组在术后腹腔内出血、感染、肠梗阻、吻合口漏、骨髓抑制等方面无统计学差异(P>0.05)。结论:腹腔热灌注化疗能够清除腹膜残留的肿瘤细胞、增强化疗药物疗效等优势,对手术后腹腔内的出血、感染、肠梗阻、骨髓抑制等短期并发症无显著差异,但可明显降低阑尾黏液腺癌患者术后复发率,提高阑尾黏液腺癌患者的总生存率。更多还原

【Abstract】 Objective : To investigate the clinical value of intraperitoneal thermoperfusion chemotherapy in the treatment of appendiceal mucinous adenocarcinoma.Methods: The clinical data of 76 patients diagnosed with appendicular mucinous adenocarcinoma in the Second Affiliated Hospital of Chongqing Medical University and The People’s Hospital of Nanchuan District of Chongqing from January 2014 to March 2020 were collected.All patients received intravenous chemotherapy after surgery,of which 35 patients received abdominal thermoperfusion chemotherapy at the same time after intravenous chemotherapy(group A).Postoperative intravenous chemotherapy was not accompanied by intraperitoneal thermal perfusion chemotherapy in 41patients(group B).The postoperative complications of abdominal bleeding,infection,intestinal obstruction,anastomotic leakage and bone marrow suppression were compared between group A and group B.The recurrence rate and survival rate of patients in the two groups were followed up six months,one year and two years after operation,and the clinical value of intraperitoneal thermal perfusion chemotherapy in the treatment of appendiceal mucinous adenocarcinoma was summarized.Results: The postoperative tumor recurrence rate of group A was lower than that of group B,and the overall survival rate was higher than that of group B,with statistical difference(P<0.05).There was no statistical difference in inhibition(P>0.05).Conclusion: Peritoneal perfusion chemotherapy can remove heat peritoneal residual tumor cells,and enhance the advantages of the chemotherapy drug curative effect,opponents of postoperative intraperitoneal hemorrhage,infection,intestinal obstruction,bone marrow suppression,short-term complications such as there was no significant difference,but can obviously reduce the appendix mucous adenocarcinoma patients postoperative recurrence rate,improve the appendix mucus gland cancer patients’ overall survival.更多还原