【作者】 刘燕；

【导师】 常颖；

【作者基本信息】 吉林大学 ， 神经病学（专业学位）， 2022， 硕士

【摘要】 背景:冲动控制障碍是帕金森病的非运动症状,并非罕见,尚缺乏有效的治疗手段,因此识别其危险因素,早期预防尤为重要,然而,关于其危险因素的研究结果存在争议,而且冲动控制障碍的发病具有明显的地域性,中国北方地区尚缺乏此类研究,本研究通过分析中国北方地区帕金森病冲动控制障碍的发病率及危险因素,旨在为其诊疗提供依据,为其后续研究提供进一步支持。方法:本研究选取就诊于吉林大学中日联谊医院神经内科的238名帕金森病患者,每个患者均进行帕金森病冲动与强迫控制障碍问卷(QUIP问卷)筛查,此问卷中病理性购物、暴饮暴食、病理性赌博、性欲亢进有一项筛查阳性即归为冲动控制障碍组,各项均为阴性的患者归为无冲动控制障碍组,比较两组患者的人口统计学特点、流行病学特点,进行危险因素分析。结果:238例帕金森病患者中31例QUIP筛查阳性,其发病率为13.0%,其中,病理性购物5.7%,暴饮暴食4.9%,病理性赌博2.4%,性欲亢进2.4%;同时具有两种或两种以上冲动控制障碍行为的患者占4.1%;两组患者在病程、是否服用多巴胺受体激动剂、每日森福罗剂量、左旋多巴日等效剂量、运动症状评分、非运动症状评分、抑郁评分、焦虑评分、快动眼睡眠行为障碍评分方面有统计学差异。结论:冲动控制障碍在帕金森病患者中并非罕见,快动眼睡眠行为障碍是其独立危险因素。更多还原

【Abstract】 Background:Impulse control disorder is a non motor symptom of Parkinson’s disease,which is not rare,and there is still a lack of effective treatment.Therefore,it is particularly important to identify its risk factors and early prevention.However,the research results on its risk factors are controversial,and the incidence of impulse control disorder has obvious regional characteristics.There is still a lack of such research in northern China.This study aims to provide evidence for further diagnosis and treatment of Parkinson disease by analyzing the incidence rate and risk factors of impulse control disorder in northern China.Methods:In this study,238 patients with Parkinson’s disease were choosed from the Department of Neurology of China-Japan Friendship Hospital Affiliated Jilin University.Each patient was screened by the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s disease(QUIP).If one of the questionnaire was positive,they were classified as impulse control disorder group,the patients who were all negative were classified into the non-impulse control disorder group.Compare the demographic and epidemiological characteristics of the two groups and analyze their risk factors.Results:Among the 238 patients with Parkinson’s disease,31 cases were positive for QUIP screening,the incidence rate was 13%,The prevalence of QUIP positivity in our patients was as follows:pathological gambling(2.4%),compulsive sexual behavior(2.4%),compulsive buying(5.7%),compulsive eating(4.9%).Patients with two or more impulse control disorders behaviors accounted for 4.1%;Longer PD duration、the use of dopamine agonists、dosage of pramipexole、daily equivalent dosage of levodopa、motor symptoms、non-motor symptom、depression、anxiety、rapid eye movement sleep behavior disorder are related to ICD.Conclusion:RBD is an independent risk factor for impulse control disorder that is not rare in patients with Parkinson’s disease.更多还原