【作者】 张睿；

【导师】 高晓彩； 龚平原；

【作者基本信息】 西北大学 ， 工程硕士（专业学位）， 2022， 硕士

【摘要】 眼睛读心是个体通过他人眼区信息识别其内心状态的重要社会认知能力。社会显著性假说认为催产素通过增强个体对显著性社会线索的注意影响社会认知能力,该效应受社会线索和个体差异的调节。已有研究主要考察了外源性催产素对眼睛读心能力的影响,没有系统考察心理状态特征和早期父母教养与催产素通路基因的交互作用对眼睛读心的影响。为丰富社会显著性假说,本研究采用分子遗传学方法考察心理状态特征和父母教养对催产素通路基因与眼睛读心能力关系的调节作用。研究一:催产素通路基因与眼睛读心能力的关系1.本研究基于两个独立样本,考察CD38和OXTR基因多态与眼睛读心能力的关系。结果显示,OXTR rs53576位点对眼睛读心正确率有显著影响,G等位基因携带者在样本一中的正确率低于AA基因型个体,在样本二中的正确率高于AA基因型个体。2.本研究基于八个独立样本对OXTR rs53576位点与眼睛读心能力的关系进行Meta分析。结果显示,GG基因型个体眼睛读心能力高于A等位基因携带者（Fixed model:d=0.124,95%CI=0.021～0.228,Z=2.367,p=0.018）。研究二:催产素通路基因与心理状态特征的交互作用对眼睛读心能力的调节作用本研究基于两个独立样本,考察催产素通路基因与心理状态特征的交互作用对眼睛读心能力的调节作用。结果显示,样本一中CD38 rs3796863位点与心理状态特征的难易程度的交互作用影响正性情绪属性的眼睛读心正确率(F_（1,547）=0.934,p=0.048,η²=0.007),OXTR rs1042778位点与心理状态特征的难易程度的交互作用影响中性情绪属性眼睛读心的正确率(F_（1,590）=5.492,p=0.019,η²<0.001);样本二中OXTR rs53576位点与心理状态特征的难易程度的交互作用影响中性情绪属性眼睛读心的正确率(F_（1,655）=5.865,p=0.016,η²=0.002)。研究三:催产素通路基因与父母教养的交互作用对眼睛读心能力的调节作用本研究基于两个独立样本,考察催产素通路基因与父母教养的交互作用对眼睛读心能力的调节作用,结果显示,CD38和OXTR基因与父母教养的交互作用在样本一和样本二中均不影响眼睛读心正确率。结论:（1）OXTR rs53576位点影响个体眼睛读心能力,GG基因型个体具有较高的眼睛读心能力;（2）心理状态特征调节催产素与眼睛读心能力的关系;（3）父母教养方式不调节催产素与眼睛读心能力的关系。意义:通过三个研究系统地考察了心理状态特征及父母教养方式对催产素通路基因与眼睛读心能力的作用,验证并进一步丰富了催产素社会显著性假说。更多还原

【Abstract】 Reading the mind in eyes is an important ability for individuals to identify other’s mental states according to the information of eye regions.The Social Salience Hypothesis states that oxytocin affects social cognition by enhancing individuals’attention to salient social cues,which is mediated by social cues and individual differences.Studies have investigated the effects of exogenous oxytocin on reading the mind in eyes,while the effects of mind state and the interaction between early parenting and oxytocin pathway genes on this ability have not been well investigated.To enrich the Social Salience Hypothesis,we investigated the effects of mind state characteristics and early parenting on the relationship between oxytocin pathway genes and reading the mind in eyes with molecular genetic methods.Study 1:The interaction between oxytocin pathway genes and reading the mind in eyes1.Based on two independent samples,we investigated the relationship between CD38 and OXTR and reading the mind in eyes.The results showed that the OXTR rs53576 significantly affected on this ability The accuracy rate of G allele carriers is lower than those with AA genotypes in the first sample,but was higher in the second sample.2.Based on eight independent samples,a meta-analysis revealed that the OXTR rs53576was associated with accuracy of reading the mind in eyes,in which the GG genotype was related to higher accuracy than the AA/AG genotype（Fixed model:d=0.124,95%CI=0.021～0.228,Z=2.367,p=0.018）.Study 2:The interaction of oxytocin pathway genes and mind state characteristics in reading the mind in eyesBased on two independent samples,we investigated the moderations of characteristics of eye regions on the relationship between oxytocin pathway genes and reading the mind in eyes.The results showed that difficulty level of identifying the information of eye regions moderated the relationship between the CD38 rs3796863 and the accuracy of reading mind in eyes of the positive emotional pictures(F_（1,547）=0.934,p=0.048,η²=0.007),and the relationship between the OXTR rs1042778 and the accuracy of reading the mind in eyes with neutral emotional pictures in first sample(F_（1,590）=5.492,p=0.019,η²<0.001);difficulty level moderated the relationship between OXTR rs53576 and the accuracy of reading the mind in eyes with neutral emotional pictures in second sample(F_（1,655）=5.865,p=0.016,η²=0.002).Study 3:The interaction of oxytocin pathway genes and parenting regulates the ability of reading mind in the eyesThis study investigated the moderations of early parenting in the relationship between oxytocin pathway genes and reading the mind in eyes with two independent samples.The results showed that parenting could not moderate the relationship between CD38,OXTR and this ability in two samples.Conclusions:（1）OXTR rs53576 affects the ability of reading the mind in eyes,such that individuals with the GG genotype show the higher ability;（2）mind state characteristics moderate the relationship between oxytocin and this ability;（3）parenting styles do not modulate the relationship between oxytocin and this ability.Significance:Three studies were conducted to investigate the effects of mind state and parenting style on oxytocin pathway genes and this ability,confirming and further enriching the Social Salience Hypothesis.更多还原