【作者】 刘艳艳；

【导师】 陈鹏；

【作者基本信息】 黑龙江中医药大学 ， 中西医结合临床（专业学位）， 2021， 硕士

【摘要】 目的:观察丹蒌饮治疗稳定型心绞痛(痰瘀互结型)患者的临床治疗效果,及其对血清白介素-6(IL-6)和白介素-17(IL-17)含量变化的影响。方法:选取病例为心血管一科门诊患者60例,且诊断为胸痹心痛(痰瘀互结型),将符合标准的病例数随机分为对照组和治疗组,每组人数30例,对照组使用常规西药治疗,治疗组则在此之上应用丹蒌饮中药汤剂治疗,治疗周期为28天。治疗前后分别检测并记录患者的中医证候积分及疗效、心绞痛症状、硝酸甘油停减率和血清IL-6和IL-17的含量变化情况,及安全指标的变化。结果:1.疗程结束后,中医证候积分方面两组均较前明显降低,且治疗组低于对照组,差异有统计学意义(p<0.05);在中医证候疗效方面,治疗组高于对照组,差异有统计学意义(p<0.05)。2.疗程结束后,心绞痛积分方面两组均较前明显下降,且治疗组低于对照组,差异有统计学意义(p<0.05);在心绞痛疗效方面,治疗组高于对照组,差异有统计学意义(p<0.05)。3.疗程结束后,治疗组硝酸甘油停减率高于对照组,差异有统计学意义(p<0.05)。4.疗程结束后,组内比较,血清IL-6、IL-17含量较治疗前均有明显下降,差异有统计学意义(p<0.05);组间进行比较,血清IL-6含量治疗组低于对照组,差异有统计学意义(p<0.05),血清IL-17含量治疗前后变化不显著,差异无统计学意义(p>0.05)。结论:1.丹蒌饮能改善SAP(痰瘀互结型)患者的中医证候情况、缓解心绞痛症状,减少硝酸甘油的使用量。2.丹蒌饮可能是通过抑制炎症因子的聚集,降低SAP(痰瘀互结型)患者血清IL-6的水平。更多还原

【Abstract】 Objective:To observe the clinical therapeutic effect of Danlou Decoction in the treatment of patients with stable angina pectoris(phlegm and blood stasis),and its effect on the changes of serum interleukin-6(IL-6)and interleukin-17(IL-17)levels.Methods: The selected cases were 60 outpatients in the first cardiovascular department,and they were diagnosed with chest pain and heartache(phlegm and blood stasis).The number of cases that met the criteria were randomly divided into a control group and a treatment group,with 30 cases in each group,and the control group used The treatment group was treated with conventional western medicine,and the treatment group was treated with Danlouyin Chinese medicine decoction on top of this,and the treatment period was 28 days.Before and after treatment,detect and record the patient’s TCM syndrome integral and curative effect,angina pectoris symptoms,nitroglycerin stop rate,serum IL-6 and IL-17 content changes,and changes in safety indicators.Result:1.After the treatment,the scores of TCM syndromes in both groups were significantly lower than before,and the treatment group was lower than the control group,the difference was statistically significant(p<0.05);in terms of the efficacy of TCM syndromes,the treatment group was higher than the control group.The difference is statistically significant(p< 0.05).2.After the course of treatment,the angina pectoris scores of the two groups were significantly lower than before,and the treatment group was lower than the control group,the difference was statistically significant(p<0.05);in terms of the efficacy of angina pectoris,the treatment group was higher than the control group,the difference was statistically significant Significance(p< 0.05).3.After the course of treatment,the reduction rate of nitroglycerin in the treatment group was higher than that in the control group,and the difference was statistically significant(p< 0.05).4.After the treatment period,the serum IL-6 and IL-17 levels were significantly lower than before the treatment,and the difference was statistically significant(p<0.05);compared between the groups,the serum IL-6 level was lower than that of the treatment group In the control group,the difference was statistically significant(p<0.05),the serum IL-17 content did not change significantly before and after treatment,and the difference was not statistically significant(p>0.05).Conclusion:1.Danlou Decoction can improve the TCM syndromes of SAP(phlegm and blood stasis)patients,relieve the symptoms of angina,and reduce the consumption of nitroglycerin.2.Danlou Decoction may reduce the level of serum IL-6 in SAP(phlegm and blood stasis)by inhibiting the accumulation of inflammatory factors.更多还原