【作者】 陈涛；

【导师】 王星；

【作者基本信息】 重庆大学 ， 生物医学工程， 2021， 硕士

【摘要】 汉语单音节词是构成汉语普通话语句的重要因素,由声母和韵母组成,不同的单音节词往往有着不同的基频范围,搭配不同音调,可以表达不同的语义,因此准确理解单音节词在人们日常交流和社会生活中具有重要意义。目前关于四种汉语音调在实验动物下丘神经元的响应模式已经有了较多的研究结果,但是对于不同音节在实验动物下丘神经元所引起的响应模式研究却比较少,关于音调和音节对神经元响应同步到语音刺激时频特征的同步程度的影响作用研究也较少,因此本文将围绕这些问题进行探索和讨论。为了了解不同汉语单音节词在动物下丘神经元的响应模式,首先提取汉语单音节词刺激中包含的基频轨迹并进行均值滤波。然后以豚鼠为动物模型,在信号屏蔽室内通过胞外记录电极采集豚鼠下丘神经元在开场汉语语音刺激下的动作电位发放数据。之后对数据进行统计分析以及可视化处理,绘制了刺激后时间直方图、峰电位间隔图等结果图并将神经元响应和语音刺激两者的时频特征进行对比分析,探讨下丘神经元在不同单音节词刺激下的发放差异,并根据结果进行详细的讨论分析。结果表明82%(23/28)的格栅图跟随程度结果、76%(128/168)的刺激后时间直方图基频和语音基频相关系数结果以及40%(67/168)的矢量强度结果均大于50%,即神经元响应表征语音时频特征的程度普遍高于50%。另一方面,四种音调的神经锁相程度只在残差结果和相关系数结果上表现出极个别的显著性差异,在另外两个指标下的结果均没有任何显著性差异。而七个音节的神经表征程度则在四个指标上均普遍表现出显著性差异,其中/wu/与剩余音节之间的结果差异最为明显。最后,音调和音节的交互影响对神经表征程度没有显著性差异。综上所述,本文从神经电生理层面进一步探究了不同汉语中的音调和音节各自影响以及两者交互影响在豚鼠下丘神经元的响应模式以及其对神经元响应同步到语音刺激的同步程度的影响作用,为使用电生理信号客观评价汉语单音节词能够在下丘中引起的响应结果提供了实验指导和理论依据。更多还原

【Abstract】 Chinese monosyllabic words are an important factor in the formation of Putonghua sentences,which are composed of initials and finals.Different monosyllabic words often have different fundamental frequency range,and can express different semantics with different tones.Therefore,it is of great significance to accurately understand monosyllabic words in people’s daily communication and social life.At present,there are many research results on the response patterns of four Chinese tones in the inferior colliculus neurons of experimental animals,but there are few studies on the response patterns caused by different syllables in the inferior colliculus neurons of experimental animals,and there are few studies on the effects of tones and syllables on the synchronization degree of neurons’ response to the time-frequency characteristics of speech stimulation,Therefore,this paper will explore and discuss these problems.In order to understand the response patterns of different Chinese monosyllabic words in animal inferior colliculus neurons,the fundamental frequency trajectories contained in the stimulation of Chinese monosyllabic words were extracted and smoothed.Then,guinea pigs were used as the animal model,and the action potential data of guinea pig inferior colliculus neurons were collected by extracellular recording electrodes in the signal shielding room.After statistical analysis and visual processing of the data,the time histogram and peak potential interval diagram after stimulation were drawn,and the time-frequency characteristics of neuron response and speech stimulation were compared and analyzed to explore the differences of inferior colliculus neurons after different monosyllabic word stimulation.According to the results,the final conclusion was drawn.The results show that 82%(23 / 28)of raster graph follow degree results,76%(128/ 168)of PSTH fundamental frequency and speech fundamental frequency correlation coefficient results and 40%(67 / 168)of vector intensity results are more than 50%,that is,the degree of neural response characterizing speech time-frequency characteristics is generally higher than 50%.On the other hand,the degree of neural lock-in of the four tones only shows very few significant differences in the results of residuals and correlation coefficients,while the degree of neural representation of seven syllables generally shows significant differences in all four indicators,among which the difference between / Wu / and the remaining syllables is the most obvious.Finally,there was no significant difference in the degree of neural representation between tone and syllable.In conclusion,by recording the action potential data of guinea pig inferior colliculus neurons evoked by Chinese monosyllabic word stimulation,this paper further explored the main effects of tones and syllables in different Chinese and their interaction effects on the response mode of guinea pig inferior colliculus neurons and their influence on the synchronization degree from neuron response synchronization to voice stimulation,It provides experimental guidance and theoretical basis for the objective evaluation of the response of Chinese monosyllabic words in the inferior colliculus by using electrophysiological signals.更多还原