【作者】 李丹；

【导师】 刘华岩；

【作者基本信息】 中国医科大学 ， 神经病学（专业学位）， 2020， 硕士

【摘要】 目的:为了更好的了解不宁腿综合征(restless legs syndrome,RLS)发病与糖尿病(diabetes mellitus,DM)之间的关系,我们对RLS与糖尿病的关系进行了系统评价和meta分析。研究方法:我们系统检索了从EMBASE和PubMed数据库建立到2019年5月已发表的文献,挑选符合纳入标准的研究。采用随机效应模型计算RLS与糖尿病关系的合并优势比(odds ratio,OR)和95%置信区间(confidence interval,CI)。结果:本分析共纳入14项观察性研究,涉及89324例患者。我们的分析显示糖尿病患者的RLS患病率明显高于非糖尿病患者(OR=1.27,95%CI:1.11-1.45,p=0.035)。结论:通过分析研究证明RLS与糖尿病之间存在统计学意义上的关系,但这种关系的潜在的机制还有待进一步的研究来阐明。更多还原

【Abstract】 Objective: a meta-analysis and systematic review was conducted in order to have a better understanding of the relationship between restless legs syndrome(RLS)and diabetes mellitus.Methods: Published literatures in EMBASE and PubMed databases from establishment to the May 2019 were systematically searched and studies fulfilled the inclusion criteria were confirmed.The pooled odds ratio and 95% confidence interval(CI)for the relationship between RLS and diabetes mellitus were calculated using the random effect model.Results: 14 observational studies were included in this analysis,involving 89,324 patients.Our analysis suggested that the prevalence of RLS in patients with diabetes mellitus was higher than patients without diabetes mellitus(OR=1.27,95%CI: 1.11-1.45,p = 0.035).Conclusion: the relationship between RLS and diabetes mellitus was proved to be statistically significant through analysis,however,its potential mechanism still need to be elaborately clarified according to further researches.更多还原